Potential Biomarkers for NSAID-Exacerbated Respiratory Disease
Asthma is a common chronic disease with several variant phenotypes and endotypes. NSAID-exacerbated respiratory disease (NERD) is one such endotype characterized by asthma, chronic rhinosinusitis (CRS) with nasal polyps, and hypersensitivity to aspirin/cyclooxygenase-1 inhibitors. NERD is more assoc...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/8160148 |
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| _version_ | 1849410465777582080 |
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| author | Hanki Park Youngwoo Choi Chang-Gyu Jung Hae-Sim Park |
| author_facet | Hanki Park Youngwoo Choi Chang-Gyu Jung Hae-Sim Park |
| author_sort | Hanki Park |
| collection | DOAJ |
| description | Asthma is a common chronic disease with several variant phenotypes and endotypes. NSAID-exacerbated respiratory disease (NERD) is one such endotype characterized by asthma, chronic rhinosinusitis (CRS) with nasal polyps, and hypersensitivity to aspirin/cyclooxygenase-1 inhibitors. NERD is more associated with severe asthma than other asthma phenotypes. Regarding diagnosis, aspirin challenge tests via the oral or bronchial route are a standard diagnostic method; reliable in vitro diagnostic tests are not available. Recent studies have reported various biomarkers of phenotype, diagnosis, and prognosis. In this review, we summarized the known potential biomarkers of NERD that are distinct from those of aspirin-tolerant asthma. We also provided an overview of the different NERD subgroups. |
| format | Article |
| id | doaj-art-7b39977eeb7b4f4fb9129537446d737f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7b39977eeb7b4f4fb9129537446d737f2025-08-20T03:35:06ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/81601488160148Potential Biomarkers for NSAID-Exacerbated Respiratory DiseaseHanki Park0Youngwoo Choi1Chang-Gyu Jung2Hae-Sim Park3Department of Allergy and Clinical Immunology, Kyungpook National University School of Medicine, Daegu, Republic of KoreaDepartment of Allergy and Clinical Immunology, Ajou University Medical Center, Suwon, Republic of KoreaDepartment of Allergy and Clinical Immunology, Ajou University Medical Center, Suwon, Republic of KoreaDepartment of Allergy and Clinical Immunology, Ajou University Medical Center, Suwon, Republic of KoreaAsthma is a common chronic disease with several variant phenotypes and endotypes. NSAID-exacerbated respiratory disease (NERD) is one such endotype characterized by asthma, chronic rhinosinusitis (CRS) with nasal polyps, and hypersensitivity to aspirin/cyclooxygenase-1 inhibitors. NERD is more associated with severe asthma than other asthma phenotypes. Regarding diagnosis, aspirin challenge tests via the oral or bronchial route are a standard diagnostic method; reliable in vitro diagnostic tests are not available. Recent studies have reported various biomarkers of phenotype, diagnosis, and prognosis. In this review, we summarized the known potential biomarkers of NERD that are distinct from those of aspirin-tolerant asthma. We also provided an overview of the different NERD subgroups.http://dx.doi.org/10.1155/2017/8160148 |
| spellingShingle | Hanki Park Youngwoo Choi Chang-Gyu Jung Hae-Sim Park Potential Biomarkers for NSAID-Exacerbated Respiratory Disease Mediators of Inflammation |
| title | Potential Biomarkers for NSAID-Exacerbated Respiratory Disease |
| title_full | Potential Biomarkers for NSAID-Exacerbated Respiratory Disease |
| title_fullStr | Potential Biomarkers for NSAID-Exacerbated Respiratory Disease |
| title_full_unstemmed | Potential Biomarkers for NSAID-Exacerbated Respiratory Disease |
| title_short | Potential Biomarkers for NSAID-Exacerbated Respiratory Disease |
| title_sort | potential biomarkers for nsaid exacerbated respiratory disease |
| url | http://dx.doi.org/10.1155/2017/8160148 |
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