The Clinical Study of Intratumoral and Peritumoral Radiomics Based on DCE-MRI for HER-2 Positive and Low Expression Prediction in Breast Cancer
Yiyan Shang,1,2,* Yunxia Wang,1,2,* Yaxin Guo,2,3 Shunian Li,2,3 Jun Liao,2,3 Menglu Hai,4 Meiyun Wang,2,3 Hongna Tan1,2 1Department of Radiology, People’s Hospital of Henan University, Zhengzhou, Henan, People’s Republic of China; 2Department of Radiology, Henan Provincial People’s...
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Dove Medical Press
2024-12-01
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| Series: | Breast Cancer: Targets and Therapy |
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| author | Shang Y Wang Y Guo Y Li S Liao J Hai M Wang M Tan H |
| author_facet | Shang Y Wang Y Guo Y Li S Liao J Hai M Wang M Tan H |
| author_sort | Shang Y |
| collection | DOAJ |
| description | Yiyan Shang,1,2,* Yunxia Wang,1,2,* Yaxin Guo,2,3 Shunian Li,2,3 Jun Liao,2,3 Menglu Hai,4 Meiyun Wang,2,3 Hongna Tan1,2 1Department of Radiology, People’s Hospital of Henan University, Zhengzhou, Henan, People’s Republic of China; 2Department of Radiology, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China; 3Department of Radiology, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 4Department of Radiology, Affiliated Cancer Hospital of Zhengzhou University & Henan Provincial Cancer Hospital, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongna Tan, Department of Radiology, People’s Hospital of Henan University & Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China, Tel +86 13526766042, Email natan2000@126.comBackground: Core biopsy sampling may not fully capture tumor heterogeneity. Radiomics provides a non-invasive method to assess tumor characteristics, including both the core and surrounding tissue, with the potential to improve the accuracy of HER-2 status prediction.Objective: To explore the clinical value of intratumoral and peritumoral radiomics features from dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for preoperative prediction of human epidermal growth factor receptor-2 (HER-2) expression status in breast cancer.Methods: Two tasks were designed, including Task1-distinguished HER-2 positive and HER-2 negative from 382 breast cancer patients and Task2-distinguished HER-2 low and HER-2 zero expression from 249 patients with HER-2 negative. Three radiomics models (intratumoral, peritumoral 5 mm, intratumoral+peritumoral 5 mm) were constructed based on decision tree, and clinical combined radiomics models were constructed with logistic regression based on clinicopathological features and radscore. The area under the curve (AUC), sensitivity, specificity, accuracy and decision curve analysis (DCA) were used to evaluate the predictive performance of models.Results: Estrogen receptor (ER), progesterone receptor (PR) and Ki67 showed statistically significant in the different groups of HER-2 expression. Additionally, magnetic resonance imaging-reported axillary lymph nodes (MRI-reported ALN) in the positive and negative groups and histological grade in the low and zero expression groups showed significant differences (all P < 0.05). For task 1, the peritumoral radiomics model outperformed the other two radiomics models, with AUC values of 0.774 and 0.727 in the training and testing sets, respectively. For task 2, intratumoral + peritumoral radiomics model in the testing set showed the best predictive performance among the three radiomics models, and the AUC values were 0.777. The addition of clinicopathological features slightly altered the AUC values in both tasks.Conclusion: Both radiomics methods based on DCE-MRI and the nomogram are helpful for preoperative prediction of HER-2 expression status.Keywords: breast cancer, human epidermal growth factor receptor-2, dynamic contrast enhanced magnetic resonance imaging, radiomics, intratumoral and peritumoral, nomogram |
| format | Article |
| id | doaj-art-7b2ffc06353a43cda9f154c24fac884a |
| institution | OA Journals |
| issn | 1179-1314 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Breast Cancer: Targets and Therapy |
| spelling | doaj-art-7b2ffc06353a43cda9f154c24fac884a2025-08-20T02:37:58ZengDove Medical PressBreast Cancer: Targets and Therapy1179-13142024-12-01Volume 1695797298369The Clinical Study of Intratumoral and Peritumoral Radiomics Based on DCE-MRI for HER-2 Positive and Low Expression Prediction in Breast CancerShang YWang YGuo YLi SLiao JHai MWang MTan HYiyan Shang,1,2,* Yunxia Wang,1,2,* Yaxin Guo,2,3 Shunian Li,2,3 Jun Liao,2,3 Menglu Hai,4 Meiyun Wang,2,3 Hongna Tan1,2 1Department of Radiology, People’s Hospital of Henan University, Zhengzhou, Henan, People’s Republic of China; 2Department of Radiology, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China; 3Department of Radiology, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 4Department of Radiology, Affiliated Cancer Hospital of Zhengzhou University & Henan Provincial Cancer Hospital, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongna Tan, Department of Radiology, People’s Hospital of Henan University & Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China, Tel +86 13526766042, Email natan2000@126.comBackground: Core biopsy sampling may not fully capture tumor heterogeneity. Radiomics provides a non-invasive method to assess tumor characteristics, including both the core and surrounding tissue, with the potential to improve the accuracy of HER-2 status prediction.Objective: To explore the clinical value of intratumoral and peritumoral radiomics features from dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for preoperative prediction of human epidermal growth factor receptor-2 (HER-2) expression status in breast cancer.Methods: Two tasks were designed, including Task1-distinguished HER-2 positive and HER-2 negative from 382 breast cancer patients and Task2-distinguished HER-2 low and HER-2 zero expression from 249 patients with HER-2 negative. Three radiomics models (intratumoral, peritumoral 5 mm, intratumoral+peritumoral 5 mm) were constructed based on decision tree, and clinical combined radiomics models were constructed with logistic regression based on clinicopathological features and radscore. The area under the curve (AUC), sensitivity, specificity, accuracy and decision curve analysis (DCA) were used to evaluate the predictive performance of models.Results: Estrogen receptor (ER), progesterone receptor (PR) and Ki67 showed statistically significant in the different groups of HER-2 expression. Additionally, magnetic resonance imaging-reported axillary lymph nodes (MRI-reported ALN) in the positive and negative groups and histological grade in the low and zero expression groups showed significant differences (all P < 0.05). For task 1, the peritumoral radiomics model outperformed the other two radiomics models, with AUC values of 0.774 and 0.727 in the training and testing sets, respectively. For task 2, intratumoral + peritumoral radiomics model in the testing set showed the best predictive performance among the three radiomics models, and the AUC values were 0.777. The addition of clinicopathological features slightly altered the AUC values in both tasks.Conclusion: Both radiomics methods based on DCE-MRI and the nomogram are helpful for preoperative prediction of HER-2 expression status.Keywords: breast cancer, human epidermal growth factor receptor-2, dynamic contrast enhanced magnetic resonance imaging, radiomics, intratumoral and peritumoral, nomogramhttps://www.dovepress.com/the-clinical-study-of-intratumoral-and-peritumoral-radiomics-based-on--peer-reviewed-fulltext-article-BCTTbreast cancerhuman epidermal growth factor receptor-2dynamic contrast enhanced magnetic resonance imagingradiomicsintratumoral and peritumoralnomogram |
| spellingShingle | Shang Y Wang Y Guo Y Li S Liao J Hai M Wang M Tan H The Clinical Study of Intratumoral and Peritumoral Radiomics Based on DCE-MRI for HER-2 Positive and Low Expression Prediction in Breast Cancer Breast Cancer: Targets and Therapy breast cancer human epidermal growth factor receptor-2 dynamic contrast enhanced magnetic resonance imaging radiomics intratumoral and peritumoral nomogram |
| title | The Clinical Study of Intratumoral and Peritumoral Radiomics Based on DCE-MRI for HER-2 Positive and Low Expression Prediction in Breast Cancer |
| title_full | The Clinical Study of Intratumoral and Peritumoral Radiomics Based on DCE-MRI for HER-2 Positive and Low Expression Prediction in Breast Cancer |
| title_fullStr | The Clinical Study of Intratumoral and Peritumoral Radiomics Based on DCE-MRI for HER-2 Positive and Low Expression Prediction in Breast Cancer |
| title_full_unstemmed | The Clinical Study of Intratumoral and Peritumoral Radiomics Based on DCE-MRI for HER-2 Positive and Low Expression Prediction in Breast Cancer |
| title_short | The Clinical Study of Intratumoral and Peritumoral Radiomics Based on DCE-MRI for HER-2 Positive and Low Expression Prediction in Breast Cancer |
| title_sort | clinical study of intratumoral and peritumoral radiomics based on dce mri for her 2 positive and low expression prediction in breast cancer |
| topic | breast cancer human epidermal growth factor receptor-2 dynamic contrast enhanced magnetic resonance imaging radiomics intratumoral and peritumoral nomogram |
| url | https://www.dovepress.com/the-clinical-study-of-intratumoral-and-peritumoral-radiomics-based-on--peer-reviewed-fulltext-article-BCTT |
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