Association between ultrasonographically measured visceral fat tissue thickness and proinflammatory adipokines in obesity
Background/Aim. Obesity status can be assessed with numerous anthropometric, morphological and functional indices and this study was designed to assess relationship among them. The aim of this study was to investigate associations between anthropometric indices, ultrasonography measurement of viscer...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2020-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800198C.pdf |
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| author | Crnobrnja Veljko Ilinčić Branislava Stokić Edita Basta-Nikolić Marijana Slankamenac Sonja Stojšić-Milosavljević Anastazija Žeravica Radmila Čabarkapa Velibor |
| author_facet | Crnobrnja Veljko Ilinčić Branislava Stokić Edita Basta-Nikolić Marijana Slankamenac Sonja Stojšić-Milosavljević Anastazija Žeravica Radmila Čabarkapa Velibor |
| author_sort | Crnobrnja Veljko |
| collection | DOAJ |
| description | Background/Aim. Obesity status can be assessed with numerous anthropometric, morphological and functional indices and this study was designed to assess relationship among them. The aim of this study was to investigate associations between anthropometric indices, ultrasonography measurement of visceral and subcutaneous fat tissue thickness and certain proinflammatory adipokines level. Methods. This cross-sectional study comprised a consecutive sample of 60 obese respondents without obesity-related comorbidities, and 20 age-matched healthy normal-weight controls. Anthropometric [body mass index (BMI), waist circumference (WC), neck circumference (NC), body fat, a body shape index (ABSI)], and ultrasonographic indices [thickness of intraabdominal fatt tissue (IAFT), visceral fat (VF), maximum subcutaneous fat (Max SFT), minimal subcutaneous fat (Min SFT)], and serum levels of chemerin and resistin were assessed in all subjects. Results. All anthropometric indices showed statistically significant differences between study groups. The mean IAFT, Max SFT, Min SFT and VF were significantly higher in the obese group compared to controls (p < 0.01, for all). Serum levels of chemerin and resistin correlated positively with BMI, percentage of fat adipose tissue (FAT, %), total FAT (kg), and VF (p < 0.05, for all). Also, we observed significant correlation between resistin and NC (r = 0.23, p = 0.03) and ABSI (r = 0.22, p = 0.04). In multivariable linear regression analysis, chemerin (β = 0.23; p = 0.008) and resistin (β = 0.43; p =0.002) were independently and significantly associated only with VF. Conclusion. Obesity indices, both classical and newer ones, are in positive, statistically significant correlation with the level of proinflammatory cytokines. Ultrasonographically measured VF thickness, independently associated with adipokine levels, may improve assessment of proinflammatory fat tissue characteristics. Further studies are needed to precisely define the use of ultrasonographic fat tissue measurements into clinical practice. |
| format | Article |
| id | doaj-art-7b2e77bbc18e4d96bfc2ef1f4af789ef |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-7b2e77bbc18e4d96bfc2ef1f4af789ef2025-08-20T01:58:05ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202020-01-0177111146115310.2298/VSP181003198C0042-84501800198CAssociation between ultrasonographically measured visceral fat tissue thickness and proinflammatory adipokines in obesityCrnobrnja Veljko0Ilinčić Branislava1Stokić Edita2Basta-Nikolić Marijana3Slankamenac Sonja4Stojšić-Milosavljević Anastazija5Žeravica Radmila6Čabarkapa Velibor7Clinical Center of Vojvodina, Center for Laboratory Medicine, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaClinical Center of Vojvodina, Center for Laboratory Medicine, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Clinical Center of Vojvodina, Clinic for Diabetes, Endocrinology and Metabolic Disease, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Clinical Center of Vojvodina, Center for Radiology, Novi Sad, SerbiaClinical Center of Vojvodina, Clinic for Diabetes, Endocrinology and Metabolic Disease, Novi Sad, SerbiaClinical Center of Vojvodina, Clinic for Diabetes, Endocrinology and Metabolic Disease, Novi Sad, Serbia + Institute for Cardiovascular Disease, Sremska Kamenica, SerbiaClinical Center of Vojvodina, Center for Laboratory Medicine, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaClinical Center of Vojvodina, Center for Laboratory Medicine, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaBackground/Aim. Obesity status can be assessed with numerous anthropometric, morphological and functional indices and this study was designed to assess relationship among them. The aim of this study was to investigate associations between anthropometric indices, ultrasonography measurement of visceral and subcutaneous fat tissue thickness and certain proinflammatory adipokines level. Methods. This cross-sectional study comprised a consecutive sample of 60 obese respondents without obesity-related comorbidities, and 20 age-matched healthy normal-weight controls. Anthropometric [body mass index (BMI), waist circumference (WC), neck circumference (NC), body fat, a body shape index (ABSI)], and ultrasonographic indices [thickness of intraabdominal fatt tissue (IAFT), visceral fat (VF), maximum subcutaneous fat (Max SFT), minimal subcutaneous fat (Min SFT)], and serum levels of chemerin and resistin were assessed in all subjects. Results. All anthropometric indices showed statistically significant differences between study groups. The mean IAFT, Max SFT, Min SFT and VF were significantly higher in the obese group compared to controls (p < 0.01, for all). Serum levels of chemerin and resistin correlated positively with BMI, percentage of fat adipose tissue (FAT, %), total FAT (kg), and VF (p < 0.05, for all). Also, we observed significant correlation between resistin and NC (r = 0.23, p = 0.03) and ABSI (r = 0.22, p = 0.04). In multivariable linear regression analysis, chemerin (β = 0.23; p = 0.008) and resistin (β = 0.43; p =0.002) were independently and significantly associated only with VF. Conclusion. Obesity indices, both classical and newer ones, are in positive, statistically significant correlation with the level of proinflammatory cytokines. Ultrasonographically measured VF thickness, independently associated with adipokine levels, may improve assessment of proinflammatory fat tissue characteristics. Further studies are needed to precisely define the use of ultrasonographic fat tissue measurements into clinical practice.http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800198C.pdfadipokinesadipose tissueanthropometrymetabolic diseasesobesityresistinseverity of illness indexultrasonography |
| spellingShingle | Crnobrnja Veljko Ilinčić Branislava Stokić Edita Basta-Nikolić Marijana Slankamenac Sonja Stojšić-Milosavljević Anastazija Žeravica Radmila Čabarkapa Velibor Association between ultrasonographically measured visceral fat tissue thickness and proinflammatory adipokines in obesity Vojnosanitetski Pregled adipokines adipose tissue anthropometry metabolic diseases obesity resistin severity of illness index ultrasonography |
| title | Association between ultrasonographically measured visceral fat tissue thickness and proinflammatory adipokines in obesity |
| title_full | Association between ultrasonographically measured visceral fat tissue thickness and proinflammatory adipokines in obesity |
| title_fullStr | Association between ultrasonographically measured visceral fat tissue thickness and proinflammatory adipokines in obesity |
| title_full_unstemmed | Association between ultrasonographically measured visceral fat tissue thickness and proinflammatory adipokines in obesity |
| title_short | Association between ultrasonographically measured visceral fat tissue thickness and proinflammatory adipokines in obesity |
| title_sort | association between ultrasonographically measured visceral fat tissue thickness and proinflammatory adipokines in obesity |
| topic | adipokines adipose tissue anthropometry metabolic diseases obesity resistin severity of illness index ultrasonography |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800198C.pdf |
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