A Case of Fulminant Meningococcemia: It Is All in the Complement
Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2017/6093695 |
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| _version_ | 1832565794247016448 |
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| author | Kellie L. Hawkins Mariah Hoffman Sonia Okuyama Sarah E. Rowan |
| author_facet | Kellie L. Hawkins Mariah Hoffman Sonia Okuyama Sarah E. Rowan |
| author_sort | Kellie L. Hawkins |
| collection | DOAJ |
| description | Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia. As this new biologic agent becomes more widely prescribed, providers should be aware of the increased risk of meningococcemia. In addition to vaccination, providers may consider the use of oral penicillin for antibiotic prophylaxis against Neisseria meningitidis in these cases of functional complement deficiency. |
| format | Article |
| id | doaj-art-7b2d36cc4dc046a5ba5119081f3026a1 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-7b2d36cc4dc046a5ba5119081f3026a12025-02-03T01:06:39ZengWileyCase Reports in Infectious Diseases2090-66252090-66332017-01-01201710.1155/2017/60936956093695A Case of Fulminant Meningococcemia: It Is All in the ComplementKellie L. Hawkins0Mariah Hoffman1Sonia Okuyama2Sarah E. Rowan3Division of Infectious Disease, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USADenver Health and Hospital Authority, Denver, CO, USADenver Health and Hospital Authority, Denver, CO, USADivision of Infectious Disease, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USAEculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia. As this new biologic agent becomes more widely prescribed, providers should be aware of the increased risk of meningococcemia. In addition to vaccination, providers may consider the use of oral penicillin for antibiotic prophylaxis against Neisseria meningitidis in these cases of functional complement deficiency.http://dx.doi.org/10.1155/2017/6093695 |
| spellingShingle | Kellie L. Hawkins Mariah Hoffman Sonia Okuyama Sarah E. Rowan A Case of Fulminant Meningococcemia: It Is All in the Complement Case Reports in Infectious Diseases |
| title | A Case of Fulminant Meningococcemia: It Is All in the Complement |
| title_full | A Case of Fulminant Meningococcemia: It Is All in the Complement |
| title_fullStr | A Case of Fulminant Meningococcemia: It Is All in the Complement |
| title_full_unstemmed | A Case of Fulminant Meningococcemia: It Is All in the Complement |
| title_short | A Case of Fulminant Meningococcemia: It Is All in the Complement |
| title_sort | case of fulminant meningococcemia it is all in the complement |
| url | http://dx.doi.org/10.1155/2017/6093695 |
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