Electrospun scaffolds for heart valve tissue engineering
A potential solution for prosthetic heart valves is tissue-engineered heart valves. Tissue-engineered heart valves (TEHVs) are designed to replicate the complex properties found in natural tissues, such as stiffness, anisotropy, and composition and organization of cells and extracellular matrix (ECM...
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Open Exploration Publishing Inc.
2025-02-01
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| Series: | Exploration of BioMat-X |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A101331/101331.pdf |
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| author | Betül Gürbüz Elif Balikci Erkan Türker Baran |
| author_facet | Betül Gürbüz Elif Balikci Erkan Türker Baran |
| author_sort | Betül Gürbüz |
| collection | DOAJ |
| description | A potential solution for prosthetic heart valves is tissue-engineered heart valves. Tissue-engineered heart valves (TEHVs) are designed to replicate the complex properties found in natural tissues, such as stiffness, anisotropy, and composition and organization of cells and extracellular matrix (ECM). Electrospinning is regarded as a highly versatile and innovative approach for fabricating numerous fibrous designs. In this review, we discuss recent developments in electrospun heart valve scaffolds, including scaffold materials, cell types, and electrospinning setups used to prepare aligned nanofibers. Despite the fact that natural biomaterials provided excellent biocompatibility, nanofibers from synthetic materials provided the required mechanical compatibility. Accordingly, most studies highlighted the benefits of designing composite heart valves using biological and synthetic polymers. Various strategies, such as the application of motorized mandrel and micropatterned collector in electrospinning were effective in controlling nanofiber alignment. Studies also showed that aligned nanofiber’s mechanical strength and anisotropic structure promote cell proliferation, and differentiation, and promote attachment. Numerous studies have reported that multiple cell sources are suitable for producing heart valves. Successful results were obtained with human umbilical vein endothelial cells (HUVECs), since they provide a convenient cell source for cellularization of valve leaflets. A higher conductivity of scaffolds was achieved by using biomaterials that conduct electricity, such as polyaniline, polypyrrole, and carbon nanotubes, which resulted in better differentiation of precursor cells to cardiomyocytes and higher cell beating rates. In light of these attributes, nanofibrous scaffolds produced through electrospinning are expected to offer numerous advantages for tissue engineering and medical applications in the near future. However, multiple challenges were identified as cell infiltration and 2D nature of nanofiber mats necessitate further engineering approaches in electrospinning procedure leaflet production. |
| format | Article |
| id | doaj-art-7b2d109e1d16488ea80b2b631ba240df |
| institution | DOAJ |
| issn | 2996-9476 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of BioMat-X |
| spelling | doaj-art-7b2d109e1d16488ea80b2b631ba240df2025-08-20T03:12:30ZengOpen Exploration Publishing Inc.Exploration of BioMat-X2996-94762025-02-012S1152310.37349/ebmx.2025.101331Electrospun scaffolds for heart valve tissue engineeringBetül Gürbüz0https://orcid.org/0000-0003-2612-3554Elif Balikci1https://orcid.org/0000-0003-0437-7705Erkan Türker Baran2https://orcid.org/0000-0002-0563-6943Department of Tissue Engineering, Hamidiye Institute of Health Sciences, University of Health Sciences Turkey, 34668 Istanbul, TurkeyDepartment of Tissue Engineering, Hamidiye Institute of Health Sciences, University of Health Sciences Turkey, 34668 Istanbul, TurkeyDepartment of Tissue Engineering, Hamidiye Institute of Health Sciences, University of Health Sciences Turkey, 34668 Istanbul, Turkey; Experimental Medicine Research and Application Center, University of Health Sciences Turkey, 34668 Istanbul, Turkey; Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Health Sciences Turkey, 34668 Istanbul, TurkeyA potential solution for prosthetic heart valves is tissue-engineered heart valves. Tissue-engineered heart valves (TEHVs) are designed to replicate the complex properties found in natural tissues, such as stiffness, anisotropy, and composition and organization of cells and extracellular matrix (ECM). Electrospinning is regarded as a highly versatile and innovative approach for fabricating numerous fibrous designs. In this review, we discuss recent developments in electrospun heart valve scaffolds, including scaffold materials, cell types, and electrospinning setups used to prepare aligned nanofibers. Despite the fact that natural biomaterials provided excellent biocompatibility, nanofibers from synthetic materials provided the required mechanical compatibility. Accordingly, most studies highlighted the benefits of designing composite heart valves using biological and synthetic polymers. Various strategies, such as the application of motorized mandrel and micropatterned collector in electrospinning were effective in controlling nanofiber alignment. Studies also showed that aligned nanofiber’s mechanical strength and anisotropic structure promote cell proliferation, and differentiation, and promote attachment. Numerous studies have reported that multiple cell sources are suitable for producing heart valves. Successful results were obtained with human umbilical vein endothelial cells (HUVECs), since they provide a convenient cell source for cellularization of valve leaflets. A higher conductivity of scaffolds was achieved by using biomaterials that conduct electricity, such as polyaniline, polypyrrole, and carbon nanotubes, which resulted in better differentiation of precursor cells to cardiomyocytes and higher cell beating rates. In light of these attributes, nanofibrous scaffolds produced through electrospinning are expected to offer numerous advantages for tissue engineering and medical applications in the near future. However, multiple challenges were identified as cell infiltration and 2D nature of nanofiber mats necessitate further engineering approaches in electrospinning procedure leaflet production.https://www.explorationpub.com/uploads/Article/A101331/101331.pdfelectrospinningtissue engineeringheart valvesnanofibers |
| spellingShingle | Betül Gürbüz Elif Balikci Erkan Türker Baran Electrospun scaffolds for heart valve tissue engineering Exploration of BioMat-X electrospinning tissue engineering heart valves nanofibers |
| title | Electrospun scaffolds for heart valve tissue engineering |
| title_full | Electrospun scaffolds for heart valve tissue engineering |
| title_fullStr | Electrospun scaffolds for heart valve tissue engineering |
| title_full_unstemmed | Electrospun scaffolds for heart valve tissue engineering |
| title_short | Electrospun scaffolds for heart valve tissue engineering |
| title_sort | electrospun scaffolds for heart valve tissue engineering |
| topic | electrospinning tissue engineering heart valves nanofibers |
| url | https://www.explorationpub.com/uploads/Article/A101331/101331.pdf |
| work_keys_str_mv | AT betulgurbuz electrospunscaffoldsforheartvalvetissueengineering AT elifbalikci electrospunscaffoldsforheartvalvetissueengineering AT erkanturkerbaran electrospunscaffoldsforheartvalvetissueengineering |