(p)ppGpp imposes graded transcriptional changes to impair motility and promote antibiotic tolerance in biofilms

(p)ppGpp imposes graded transcriptional changes to impair motility and promote antibiotic tolerance in biofilms

Abstract (p)ppGpp is the master regulator of bacterial stress responses, orchestrating cellular physiology via the stringent response to promote survival and adaptation. In response to nutritional challenges and stress, (p)ppGpp extensively rewires the transcriptome. Here, we demonstrate that (p)ppG...

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Main Authors: Florian Engelhardt, Kathryn Turnbull, Melisa Gür, Mathias Müsken, Matthias Preusse, Susanne Häussler, Mohammad Roghanian
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-025-00795-7
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