Ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicity
Abstract Background The purpose of this work was to examine the fundamental mechanisms of reproductive toxicity in rat models following exposure to Fenpropathrin (FNP). Furthermore, our study explores the novel impacts of Date palm kernel extract (DPK) on these detrimental outcomes. Methods Thirty m...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | Biological Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40659-025-00605-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850277713108008960 |
|---|---|
| author | Maher M. Soliman Marsail S. Nashed Eman I. Hassanen Marwa Y. Issa Abdelbary M. Prince Ahmed M. Hussien Adel F. Tohamy |
| author_facet | Maher M. Soliman Marsail S. Nashed Eman I. Hassanen Marwa Y. Issa Abdelbary M. Prince Ahmed M. Hussien Adel F. Tohamy |
| author_sort | Maher M. Soliman |
| collection | DOAJ |
| description | Abstract Background The purpose of this work was to examine the fundamental mechanisms of reproductive toxicity in rat models following exposure to Fenpropathrin (FNP). Furthermore, our study explores the novel impacts of Date palm kernel extract (DPK) on these detrimental outcomes. Methods Thirty male Wistar rats were used in the investigation. They were split into six groups: one group received corn oil as a control; two groups received DPK at 200 mg/kg and 400 mg/kg; a group received FNP at 4.7 mg/kg; and two combination groups received DPK and FNP at 200 mg/kg and 400 mg/kg, respectively for 60 days. Results FNP caused oxidative stress, reduced sperm count, and impaired motility. FNP decreased the expression of the StAR gene and reduced serum testosterone levels. We assessed the histological alterations. In a dose-dependent way, the concurrent administration of DPK extract successfully decreased all the toxicological parameters. Conclusions When taken orally, DPK extract may protect against FNP-induced male reproductive toxicity. |
| format | Article |
| id | doaj-art-7b2a2cbe62ef4184a382077bcea07f7e |
| institution | OA Journals |
| issn | 0717-6287 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj-art-7b2a2cbe62ef4184a382077bcea07f7e2025-08-20T01:49:46ZengBMCBiological Research0717-62872025-05-0158111810.1186/s40659-025-00605-6Ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicityMaher M. Soliman0Marsail S. Nashed1Eman I. Hassanen2Marwa Y. Issa3Abdelbary M. Prince4Ahmed M. Hussien5Adel F. Tohamy6Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo UniversityDepartment of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo UniversityDepartment of Pathology, Faculty of Veterinary Medicine, Cairo UniversityDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo UniversityDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo UniversityDepartment of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo UniversityDepartment of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo UniversityAbstract Background The purpose of this work was to examine the fundamental mechanisms of reproductive toxicity in rat models following exposure to Fenpropathrin (FNP). Furthermore, our study explores the novel impacts of Date palm kernel extract (DPK) on these detrimental outcomes. Methods Thirty male Wistar rats were used in the investigation. They were split into six groups: one group received corn oil as a control; two groups received DPK at 200 mg/kg and 400 mg/kg; a group received FNP at 4.7 mg/kg; and two combination groups received DPK and FNP at 200 mg/kg and 400 mg/kg, respectively for 60 days. Results FNP caused oxidative stress, reduced sperm count, and impaired motility. FNP decreased the expression of the StAR gene and reduced serum testosterone levels. We assessed the histological alterations. In a dose-dependent way, the concurrent administration of DPK extract successfully decreased all the toxicological parameters. Conclusions When taken orally, DPK extract may protect against FNP-induced male reproductive toxicity.https://doi.org/10.1186/s40659-025-00605-6Date palm kernelFenpropathrinTestosteroneOxidative stressCaspase 3StAR gene |
| spellingShingle | Maher M. Soliman Marsail S. Nashed Eman I. Hassanen Marwa Y. Issa Abdelbary M. Prince Ahmed M. Hussien Adel F. Tohamy Ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicity Biological Research Date palm kernel Fenpropathrin Testosterone Oxidative stress Caspase 3 StAR gene |
| title | Ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicity |
| title_full | Ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicity |
| title_fullStr | Ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicity |
| title_full_unstemmed | Ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicity |
| title_short | Ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicity |
| title_sort | ameliorative effects of date palm kernel extract against fenpropathrin induced male reproductive toxicity |
| topic | Date palm kernel Fenpropathrin Testosterone Oxidative stress Caspase 3 StAR gene |
| url | https://doi.org/10.1186/s40659-025-00605-6 |
| work_keys_str_mv | AT mahermsoliman ameliorativeeffectsofdatepalmkernelextractagainstfenpropathrininducedmalereproductivetoxicity AT marsailsnashed ameliorativeeffectsofdatepalmkernelextractagainstfenpropathrininducedmalereproductivetoxicity AT emanihassanen ameliorativeeffectsofdatepalmkernelextractagainstfenpropathrininducedmalereproductivetoxicity AT marwayissa ameliorativeeffectsofdatepalmkernelextractagainstfenpropathrininducedmalereproductivetoxicity AT abdelbarymprince ameliorativeeffectsofdatepalmkernelextractagainstfenpropathrininducedmalereproductivetoxicity AT ahmedmhussien ameliorativeeffectsofdatepalmkernelextractagainstfenpropathrininducedmalereproductivetoxicity AT adelftohamy ameliorativeeffectsofdatepalmkernelextractagainstfenpropathrininducedmalereproductivetoxicity |