Pandemic Events Caused by Bacteria Throughout Human History and the Risks of Antimicrobial Resistance Today
During human history, many pandemic events have threatened and taken many human lives over the years. The deadliest outbreaks were caused by bacteria such as <i>Yersinia pestis</i>. Nowadays, antimicrobial resistance (AMR) in bacteria is a huge problem for the public worldwide, threateni...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/2/457 |
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| author | Pedro Filho Noronha Souza Nicholas Silva dos Santos Filho João Lucas Timbó Mororó Daiane Maria da Silva Brito Ana Beatriz da Lima Felipe Pantoja Mesquita Raquel Carvalho Montenegro |
| author_facet | Pedro Filho Noronha Souza Nicholas Silva dos Santos Filho João Lucas Timbó Mororó Daiane Maria da Silva Brito Ana Beatriz da Lima Felipe Pantoja Mesquita Raquel Carvalho Montenegro |
| author_sort | Pedro Filho Noronha Souza |
| collection | DOAJ |
| description | During human history, many pandemic events have threatened and taken many human lives over the years. The deadliest outbreaks were caused by bacteria such as <i>Yersinia pestis</i>. Nowadays, antimicrobial resistance (AMR) in bacteria is a huge problem for the public worldwide, threatening and taking many lives each year. The present work aimed to gather current evidence published in scientific literature that addresses AMR risks. A literature review was conducted using the following descriptors: antimicrobial resistance, AMR, bacteria, and Boolean operators. The results showed that antimicrobial-resistant genes and antibiotic-resistant bacteria in organisms cause critical infectious diseases and are responsible for the infections caused by antibiotic-resistant bacteria (ARB). This review emphasizes the importance of this topic. It sheds light on the risk of reemerging infections and their relationship with AMR. In addition, it discusses the mechanisms and actions of antibiotics and the mechanisms behind the development of resistance by bacteria, focusing on demonstrating the importance of the search for new drugs, for which research involving peptides is fundamental. |
| format | Article |
| id | doaj-art-7b29733ffd504f41b4d60fb347daf3c8 |
| institution | DOAJ |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-7b29733ffd504f41b4d60fb347daf3c82025-08-20T02:44:47ZengMDPI AGMicroorganisms2076-26072025-02-0113245710.3390/microorganisms13020457Pandemic Events Caused by Bacteria Throughout Human History and the Risks of Antimicrobial Resistance TodayPedro Filho Noronha Souza0Nicholas Silva dos Santos Filho1João Lucas Timbó Mororó2Daiane Maria da Silva Brito3Ana Beatriz da Lima4Felipe Pantoja Mesquita5Raquel Carvalho Montenegro6Laboratory of Bioinformatics Applied to Health, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilLaboratory of Bioinformatics Applied to Health, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilLaboratory of Bioinformatics Applied to Health, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilLaboratory of Bioinformatics Applied to Health, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilLaboratory of Bioinformatics Applied to Health, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilLaboratory of Bioinformatics Applied to Health, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilLaboratory of Bioinformatics Applied to Health, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza 60430-275, CE, BrazilDuring human history, many pandemic events have threatened and taken many human lives over the years. The deadliest outbreaks were caused by bacteria such as <i>Yersinia pestis</i>. Nowadays, antimicrobial resistance (AMR) in bacteria is a huge problem for the public worldwide, threatening and taking many lives each year. The present work aimed to gather current evidence published in scientific literature that addresses AMR risks. A literature review was conducted using the following descriptors: antimicrobial resistance, AMR, bacteria, and Boolean operators. The results showed that antimicrobial-resistant genes and antibiotic-resistant bacteria in organisms cause critical infectious diseases and are responsible for the infections caused by antibiotic-resistant bacteria (ARB). This review emphasizes the importance of this topic. It sheds light on the risk of reemerging infections and their relationship with AMR. In addition, it discusses the mechanisms and actions of antibiotics and the mechanisms behind the development of resistance by bacteria, focusing on demonstrating the importance of the search for new drugs, for which research involving peptides is fundamental.https://www.mdpi.com/2076-2607/13/2/457antimicrobial resistancebacterial resistanceantimicrobial peptides |
| spellingShingle | Pedro Filho Noronha Souza Nicholas Silva dos Santos Filho João Lucas Timbó Mororó Daiane Maria da Silva Brito Ana Beatriz da Lima Felipe Pantoja Mesquita Raquel Carvalho Montenegro Pandemic Events Caused by Bacteria Throughout Human History and the Risks of Antimicrobial Resistance Today Microorganisms antimicrobial resistance bacterial resistance antimicrobial peptides |
| title | Pandemic Events Caused by Bacteria Throughout Human History and the Risks of Antimicrobial Resistance Today |
| title_full | Pandemic Events Caused by Bacteria Throughout Human History and the Risks of Antimicrobial Resistance Today |
| title_fullStr | Pandemic Events Caused by Bacteria Throughout Human History and the Risks of Antimicrobial Resistance Today |
| title_full_unstemmed | Pandemic Events Caused by Bacteria Throughout Human History and the Risks of Antimicrobial Resistance Today |
| title_short | Pandemic Events Caused by Bacteria Throughout Human History and the Risks of Antimicrobial Resistance Today |
| title_sort | pandemic events caused by bacteria throughout human history and the risks of antimicrobial resistance today |
| topic | antimicrobial resistance bacterial resistance antimicrobial peptides |
| url | https://www.mdpi.com/2076-2607/13/2/457 |
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