Beyond bronchial thermoplasty – where to now?
Summary: With the impending ‘retirement’ of bronchial thermoplasty (BT) for the treatment of patients with asthma, there is much to learn from this real-world experiment that will help us develop more effective future therapies with the same primary target i.e., airway smooth muscle (ASM) remodellin...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | EClinicalMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537024005960 |
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| author | Peter B. Noble David Langton Chuan T. Foo Bruce R. Thompson Alvenia Cairncross Michael J. Hackmann Francis Thien Graham M. Donovan |
| author_facet | Peter B. Noble David Langton Chuan T. Foo Bruce R. Thompson Alvenia Cairncross Michael J. Hackmann Francis Thien Graham M. Donovan |
| author_sort | Peter B. Noble |
| collection | DOAJ |
| description | Summary: With the impending ‘retirement’ of bronchial thermoplasty (BT) for the treatment of patients with asthma, there is much to learn from this real-world experiment that will help us develop more effective future therapies with the same primary target i.e., airway smooth muscle (ASM) remodelling. This viewpoint discusses initial controversy surrounding BT (lack of an effect on forced expiratory volume in 1 s), its underutilisation, and importantly how non-standard diagnostics successfully demonstrated therapeutic response which escaped traditional lung function metrics. It is anticipated that the next iteration of BT (likely in a drug form) will have an overall greater effect on the health care system by virtue of evoking ASM remodelling as a treatable trait, and after appropriately drawing on lessons learned from the ∼fifteen-year BT saga. |
| format | Article |
| id | doaj-art-7b2617bb5f524f388af1fd0066ce2493 |
| institution | Kabale University |
| issn | 2589-5370 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj-art-7b2617bb5f524f388af1fd0066ce24932025-01-22T05:43:43ZengElsevierEClinicalMedicine2589-53702025-01-0179103017Beyond bronchial thermoplasty – where to now?Peter B. Noble0David Langton1Chuan T. Foo2Bruce R. Thompson3Alvenia Cairncross4Michael J. Hackmann5Francis Thien6Graham M. Donovan7School of Human Sciences, The University of Western Australia, WA, Australia; Corresponding author. School of Human Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, 6009, WA, Australia.Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia; Department of Thoracic Medicine, Peninsula Health, Frankston, VIC, AustraliaFaculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia; Department of Respiratory Medicine, Eastern Health, Melbourne, VIC, AustraliaSchool of Health Sciences, University of Melbourne, VIC, AustraliaSchool of Human Sciences, The University of Western Australia, WA, Australia; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, WA, AustraliaSchool of Human Sciences, The University of Western Australia, WA, AustraliaFaculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia; Department of Respiratory Medicine, Eastern Health, Melbourne, VIC, AustraliaDepartment of Mathematics, University of Auckland, Auckland, New ZealandSummary: With the impending ‘retirement’ of bronchial thermoplasty (BT) for the treatment of patients with asthma, there is much to learn from this real-world experiment that will help us develop more effective future therapies with the same primary target i.e., airway smooth muscle (ASM) remodelling. This viewpoint discusses initial controversy surrounding BT (lack of an effect on forced expiratory volume in 1 s), its underutilisation, and importantly how non-standard diagnostics successfully demonstrated therapeutic response which escaped traditional lung function metrics. It is anticipated that the next iteration of BT (likely in a drug form) will have an overall greater effect on the health care system by virtue of evoking ASM remodelling as a treatable trait, and after appropriately drawing on lessons learned from the ∼fifteen-year BT saga.http://www.sciencedirect.com/science/article/pii/S2589537024005960Airway smooth muscleBronchial thermoplastyAsthmaStructure-guided therapy |
| spellingShingle | Peter B. Noble David Langton Chuan T. Foo Bruce R. Thompson Alvenia Cairncross Michael J. Hackmann Francis Thien Graham M. Donovan Beyond bronchial thermoplasty – where to now? EClinicalMedicine Airway smooth muscle Bronchial thermoplasty Asthma Structure-guided therapy |
| title | Beyond bronchial thermoplasty – where to now? |
| title_full | Beyond bronchial thermoplasty – where to now? |
| title_fullStr | Beyond bronchial thermoplasty – where to now? |
| title_full_unstemmed | Beyond bronchial thermoplasty – where to now? |
| title_short | Beyond bronchial thermoplasty – where to now? |
| title_sort | beyond bronchial thermoplasty where to now |
| topic | Airway smooth muscle Bronchial thermoplasty Asthma Structure-guided therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2589537024005960 |
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