Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v

Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v

Background SOT201 and its murine surrogate mSOT201 are novel cis-acting immunocytokines consisting of a humanized/murinized/, Fc-silenced anti-programmed cell death protein 1 (PD-1) monoclonal antibody (mAb) fused to an attenuated human interleukin (IL)-15 and the IL-15Rα sushi+ domain. Murine mPD1-...

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Main Authors: Ulrich Moebius, Radek Špíšek, David Béchard, Zuzana Antosova, Nada Podzimkova, Irena Adkins, Klara Danova, Ekaterina Simonova, Katerina Behalova, Petr Danek, Matej Fabisik, Kamila Hladikova, Lucie Kosinova, Pavel Marasek, Vladyslav Mazhara, Katerina Sajnerova, Milada Sirova, Marek Kovar, Martin Steegmaier, Hana Matuskova, Iva Malatova, Klara Hrabankova, Denise Greco, Ondrej Martinec, Romana Mikyskova, Milan Reinis, Lenka Palova Jelinkova
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/4/e010736.full
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