Change in lung function abnormalities in patients treated for first ever pulmonary tuberculosis in Dar es Salaam, Tanzania
Objectives: To document abnormalities in pulmonary function (PF) and associated factors in patients completing treatment for microbiologically confirmed, first-ever pulmonary tuberculosis (PTB).From August 2020 to May 2021, we recruited 332 patients aged ≥15 years. PF was evaluated at baseline and a...
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Elsevier
2025-08-01
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| Series: | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405579425000294 |
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| author | Reinhard Elisania Lema Grace Ambrose Shayo Zuhura Nkrumbih Tumaini Joseph Nagu |
| author_facet | Reinhard Elisania Lema Grace Ambrose Shayo Zuhura Nkrumbih Tumaini Joseph Nagu |
| author_sort | Reinhard Elisania Lema |
| collection | DOAJ |
| description | Objectives: To document abnormalities in pulmonary function (PF) and associated factors in patients completing treatment for microbiologically confirmed, first-ever pulmonary tuberculosis (PTB).From August 2020 to May 2021, we recruited 332 patients aged ≥15 years. PF was evaluated at baseline and at treatment completion. The Wilcoxon signed-rank test was used to compare median PF changes between baseline and treatment completion. A log-binomial regression model was used to determine factors associated with abnormal PF at treatment completion. Statistical significance was set at p ≤ 0.05. Results: Abnormal PF was observed in 142 of 300 (47.3 %) patients who completed the study. Being male (RR [95 % CI] = 1.22 [1.19–2.23]), underweight (RR = 1.49 [1.13–1.95]), having lung cavitation (RR = 1.90 [1.29–2.78]), and lung fibrosis at baseline (RR = 2.16 [1.32–3.53]) were significantly associated with abnormal PF. The median (IQR) FEV1 at treatment completion was 2.33 L (0.90–4.23 L) and FVC was 3.05 L (1.10–7.50 L), both significantly higher than FEV1 of 2.18 L (0.20–5.70 L) and FVC of 2.82 L (0.26–7.05 L) at treatment initiation (p < 0.05 for both). Conclusion: Approximately half of the patients had abnormal PF at treatment completion. Underweight patients, males, and those with lung cavitation at treatment initiation are more likely to have abnormal PF at the end of treatment and may require special attention. |
| format | Article |
| id | doaj-art-7b20a30cc8a1422fa2597cdd7ec1de60 |
| institution | Kabale University |
| issn | 2405-5794 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
| spelling | doaj-art-7b20a30cc8a1422fa2597cdd7ec1de602025-08-20T03:42:10ZengElsevierJournal of Clinical Tuberculosis and Other Mycobacterial Diseases2405-57942025-08-014010053810.1016/j.jctube.2025.100538Change in lung function abnormalities in patients treated for first ever pulmonary tuberculosis in Dar es Salaam, TanzaniaReinhard Elisania Lema0Grace Ambrose Shayo1Zuhura Nkrumbih2Tumaini Joseph Nagu3Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, P. O. Box 65001, Dar es Salaam, Tanzania; Department of Internal Medicine, Rabininsia Memorial Hospital, P.O. Box 67497, Dar es Salaam TanzaniaDepartment of Internal Medicine, Muhimbili University of Health and Allied Sciences, P. O. Box 65001, Dar es Salaam, Tanzania; Corresponding author.Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, P. O. Box 65001, Dar es Salaam, TanzaniaDepartment of Internal Medicine, Muhimbili University of Health and Allied Sciences, P. O. Box 65001, Dar es Salaam, TanzaniaObjectives: To document abnormalities in pulmonary function (PF) and associated factors in patients completing treatment for microbiologically confirmed, first-ever pulmonary tuberculosis (PTB).From August 2020 to May 2021, we recruited 332 patients aged ≥15 years. PF was evaluated at baseline and at treatment completion. The Wilcoxon signed-rank test was used to compare median PF changes between baseline and treatment completion. A log-binomial regression model was used to determine factors associated with abnormal PF at treatment completion. Statistical significance was set at p ≤ 0.05. Results: Abnormal PF was observed in 142 of 300 (47.3 %) patients who completed the study. Being male (RR [95 % CI] = 1.22 [1.19–2.23]), underweight (RR = 1.49 [1.13–1.95]), having lung cavitation (RR = 1.90 [1.29–2.78]), and lung fibrosis at baseline (RR = 2.16 [1.32–3.53]) were significantly associated with abnormal PF. The median (IQR) FEV1 at treatment completion was 2.33 L (0.90–4.23 L) and FVC was 3.05 L (1.10–7.50 L), both significantly higher than FEV1 of 2.18 L (0.20–5.70 L) and FVC of 2.82 L (0.26–7.05 L) at treatment initiation (p < 0.05 for both). Conclusion: Approximately half of the patients had abnormal PF at treatment completion. Underweight patients, males, and those with lung cavitation at treatment initiation are more likely to have abnormal PF at the end of treatment and may require special attention.http://www.sciencedirect.com/science/article/pii/S2405579425000294Pulmonary functionsTuberculosisFEV1FVCPulmonary tuberculosis |
| spellingShingle | Reinhard Elisania Lema Grace Ambrose Shayo Zuhura Nkrumbih Tumaini Joseph Nagu Change in lung function abnormalities in patients treated for first ever pulmonary tuberculosis in Dar es Salaam, Tanzania Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Pulmonary functions Tuberculosis FEV1 FVC Pulmonary tuberculosis |
| title | Change in lung function abnormalities in patients treated for first ever pulmonary tuberculosis in Dar es Salaam, Tanzania |
| title_full | Change in lung function abnormalities in patients treated for first ever pulmonary tuberculosis in Dar es Salaam, Tanzania |
| title_fullStr | Change in lung function abnormalities in patients treated for first ever pulmonary tuberculosis in Dar es Salaam, Tanzania |
| title_full_unstemmed | Change in lung function abnormalities in patients treated for first ever pulmonary tuberculosis in Dar es Salaam, Tanzania |
| title_short | Change in lung function abnormalities in patients treated for first ever pulmonary tuberculosis in Dar es Salaam, Tanzania |
| title_sort | change in lung function abnormalities in patients treated for first ever pulmonary tuberculosis in dar es salaam tanzania |
| topic | Pulmonary functions Tuberculosis FEV1 FVC Pulmonary tuberculosis |
| url | http://www.sciencedirect.com/science/article/pii/S2405579425000294 |
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