Muscle very long-chain ceramides associate with insulin resistance independently of obesity

Muscle very long-chain ceramides associate with insulin resistance independently of obesity

Lipids, in particular ceramides and diacylglycerols (DAGs), are implicated in insulin resistance (IR), however their precise roles remain unclear. Here, we leverage natural genetic variation to examine muscle lipids and systemic IR in 399 Diversity Outbred Australia mice fed either chow or a high-fa...

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Main Authors: Søren Madsen, Harry B. Cutler, Kristen C. Cooke, Meg Potter, Jasmine Khor, Christoph D. Rau, Stewart WC. Masson, Anna Howell, Zora Modrusan, Anthony S. Don, Jacqueline Stöckli, Alexis Diaz Vegas, David E. James
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Metabolism
Subjects:
Insulin resistance
Skeletal muscle
Lipids
Ceramides
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782500119X
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http://www.sciencedirect.com/science/article/pii/S221287782500119X

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