Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy
Preoperative parathyroid evaluation through nuclear medicine and intraoperative hormone monitoring has significantly increased the success of the surgical intervention. Material and method: Our study is descriptive, the database is retrospective but it is maintained prospectively. The preoperative p...
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Bucharest College of Physicians
2023-06-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2023/06/Intraoperative-Post-parathyroidectomy-Correlation-of-PTH-Hormone-Values-with-Preoperative-Scintigraphy.pdf |
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| author | Iulian SLAVU Cornelia NITIPIR Cristina ORLOV-SLAVU Alexandru DOGARU Raluca TULIN Constantin OPRESCU Adrian TULIN |
| author_facet | Iulian SLAVU Cornelia NITIPIR Cristina ORLOV-SLAVU Alexandru DOGARU Raluca TULIN Constantin OPRESCU Adrian TULIN |
| author_sort | Iulian SLAVU |
| collection | DOAJ |
| description | Preoperative parathyroid evaluation through nuclear medicine and intraoperative hormone monitoring has significantly increased the success of the surgical intervention. Material and method: Our study is descriptive, the database is retrospective but it is maintained prospectively. The preoperative protocol included single photon emission computed tomography (SPECT) with the use of technetium-99 sestamibi tracer. We preferred this approach as it allowed 3-D localization of the adenomas. PTH values were obtained from blood drawn from the ipsilateral jugular vein at the regular intervals of 5, 10 and 15 minutes post excision. Results: We had 6 cases with false negative which led to the necessary dissection of the contralateral neck. Two had previous surgery and 4 had tumors in other locations which were observed after the surgical intervention through methodical investigations. We encountered 3 patients with false positive results. 2 had intrathyroidal adenomas and 1 was diagnosed with thyroid papillary carcinoma. Causes of a misinterpretation are related to thyroid disease in association with hyperparathyroidism, a history of parathyroid surgery or multiple locations of hyperproductive parathyroid glands. |
| format | Article |
| id | doaj-art-7b1d7d72fa7d4c77a8a29e85d3153eae |
| institution | OA Journals |
| issn | 1223-0472 2360-2473 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Bucharest College of Physicians |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj-art-7b1d7d72fa7d4c77a8a29e85d3153eae2025-08-20T02:07:02ZengBucharest College of PhysiciansModern Medicine1223-04722360-24732023-06-013029599https://doi.org/10.31689/rmm.2023.30.2.95Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative ScintigraphyIulian SLAVU0Cornelia NITIPIR1https://orcid.org/0000-0002-5985-3759Cristina ORLOV-SLAVU2Alexandru DOGARU3Raluca TULIN4Constantin OPRESCU5Adrian TULIN6Anatomy Department, University of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaOncology Department of the University of Medicine and Pharmacy “Carol Davila”, Bucharest, "Elias" Hospital, RomaniaOncology Department of the University of Medicine and Pharmacy “Carol Davila”, Bucharest, "Elias" Hospital, RomaniaAnatomy Department, University of Medicine and Pharmacy “Carol Davila”, Bucharest, RomaniaEndocrinology Department of the University of Medicine and Pharmacy “Carol Davila”, Bucharest, "Agrippa Ionescu" Hospital, RomaniaGeneral Surgery Department of the University of Medicine and Pharmacy “Carol Davila”, Bucharest, "Floreasca" Hospital, RomaniaGeneral Surgery Department of the University of Medicine and Pharmacy “Carol Davila”, Bucharest, "Floreasca" Hospital, RomaniaPreoperative parathyroid evaluation through nuclear medicine and intraoperative hormone monitoring has significantly increased the success of the surgical intervention. Material and method: Our study is descriptive, the database is retrospective but it is maintained prospectively. The preoperative protocol included single photon emission computed tomography (SPECT) with the use of technetium-99 sestamibi tracer. We preferred this approach as it allowed 3-D localization of the adenomas. PTH values were obtained from blood drawn from the ipsilateral jugular vein at the regular intervals of 5, 10 and 15 minutes post excision. Results: We had 6 cases with false negative which led to the necessary dissection of the contralateral neck. Two had previous surgery and 4 had tumors in other locations which were observed after the surgical intervention through methodical investigations. We encountered 3 patients with false positive results. 2 had intrathyroidal adenomas and 1 was diagnosed with thyroid papillary carcinoma. Causes of a misinterpretation are related to thyroid disease in association with hyperparathyroidism, a history of parathyroid surgery or multiple locations of hyperproductive parathyroid glands.https://medicinamoderna.ro/wp-content/uploads/2023/06/Intraoperative-Post-parathyroidectomy-Correlation-of-PTH-Hormone-Values-with-Preoperative-Scintigraphy.pdfhyperparathyroidismsestaimibisurgery |
| spellingShingle | Iulian SLAVU Cornelia NITIPIR Cristina ORLOV-SLAVU Alexandru DOGARU Raluca TULIN Constantin OPRESCU Adrian TULIN Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy Modern Medicine hyperparathyroidism sestaimibi surgery |
| title | Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy |
| title_full | Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy |
| title_fullStr | Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy |
| title_full_unstemmed | Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy |
| title_short | Intraoperative Post-parathyroidectomy Correlation of PTH Hormone Values with Preoperative Scintigraphy |
| title_sort | intraoperative post parathyroidectomy correlation of pth hormone values with preoperative scintigraphy |
| topic | hyperparathyroidism sestaimibi surgery |
| url | https://medicinamoderna.ro/wp-content/uploads/2023/06/Intraoperative-Post-parathyroidectomy-Correlation-of-PTH-Hormone-Values-with-Preoperative-Scintigraphy.pdf |
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