SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMA
Goal of the study: evaluation of the impact of single nucleotide polymorphism (SNP) of rs4129267 gene of interleukin 6 receptor, (IL6R), rs1051730 gene of nicotine receptor 3 (CHRNA3) in the formation of predisposition to asthma among citizens of Krasnoyarsk.Materials and methods. Group of asthma pa...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2016-12-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/864 |
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| author | I. I. Cherkashina A. V. Razvodovskaya S. Yu. Nikulina V. N. Maksimov A. B. Averianov |
| author_facet | I. I. Cherkashina A. V. Razvodovskaya S. Yu. Nikulina V. N. Maksimov A. B. Averianov |
| author_sort | I. I. Cherkashina |
| collection | DOAJ |
| description | Goal of the study: evaluation of the impact of single nucleotide polymorphism (SNP) of rs4129267 gene of interleukin 6 receptor, (IL6R), rs1051730 gene of nicotine receptor 3 (CHRNA3) in the formation of predisposition to asthma among citizens of Krasnoyarsk.Materials and methods. Group of asthma patients included 100 persons while control group included 290 persons. The control group included population sample of relatively healthy people without broncho-pulmonary disorders, residing in Novosibirsk and examined within framework of the international projects of MONICA (Multinational MONItoring of trends and determinants in СArdiovascular disease) and HAPIEE (Health, Alcohol and Psychosocial factors In Eastern Europe).Results of the study. The association was detected between non-allergic asthma and SNP rs4129267 of gene IL6R. The association of asthma with rs1051730 of gene CHRNA3 has not been confirmed. |
| format | Article |
| id | doaj-art-7b1832ced3e04e77bf13196cfbb403da |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2016-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-7b1832ced3e04e77bf13196cfbb403da2025-08-20T02:05:55ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062016-12-019412263210.21292/2075-1230-2016-94-12-26-32864SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMAI. I. Cherkashina0A. V. Razvodovskaya1S. Yu. Nikulina2V. N. Maksimov3A. B. Averianov4V. F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityKrasnoyarsk Inter-Regional Clinical Hospital no. 4V. F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityResearch Institute of Therapy and Preventive MedicineV. F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityGoal of the study: evaluation of the impact of single nucleotide polymorphism (SNP) of rs4129267 gene of interleukin 6 receptor, (IL6R), rs1051730 gene of nicotine receptor 3 (CHRNA3) in the formation of predisposition to asthma among citizens of Krasnoyarsk.Materials and methods. Group of asthma patients included 100 persons while control group included 290 persons. The control group included population sample of relatively healthy people without broncho-pulmonary disorders, residing in Novosibirsk and examined within framework of the international projects of MONICA (Multinational MONItoring of trends and determinants in СArdiovascular disease) and HAPIEE (Health, Alcohol and Psychosocial factors In Eastern Europe).Results of the study. The association was detected between non-allergic asthma and SNP rs4129267 of gene IL6R. The association of asthma with rs1051730 of gene CHRNA3 has not been confirmed.https://www.tibl-journal.com/jour/article/view/864rs4129267 гена il6rrs1051730 гена chrna3asthmaallelesgenotypessingle nucleotide polymorphismrs4129267 of gene il6rrs1051730 of gene chrna3 |
| spellingShingle | I. I. Cherkashina A. V. Razvodovskaya S. Yu. Nikulina V. N. Maksimov A. B. Averianov SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMA Туберкулез и болезни лёгких rs4129267 гена il6r rs1051730 гена chrna3 asthma alleles genotypes single nucleotide polymorphism rs4129267 of gene il6r rs1051730 of gene chrna3 |
| title | SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMA |
| title_full | SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMA |
| title_fullStr | SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMA |
| title_full_unstemmed | SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMA |
| title_short | SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMA |
| title_sort | specific features of genetic predisposition to asthma |
| topic | rs4129267 гена il6r rs1051730 гена chrna3 asthma alleles genotypes single nucleotide polymorphism rs4129267 of gene il6r rs1051730 of gene chrna3 |
| url | https://www.tibl-journal.com/jour/article/view/864 |
| work_keys_str_mv | AT iicherkashina specificfeaturesofgeneticpredispositiontoasthma AT avrazvodovskaya specificfeaturesofgeneticpredispositiontoasthma AT syunikulina specificfeaturesofgeneticpredispositiontoasthma AT vnmaksimov specificfeaturesofgeneticpredispositiontoasthma AT abaverianov specificfeaturesofgeneticpredispositiontoasthma |