Prevention and treatment of antibiotics-associated adverse effects through the use of probiotics: A review

Background: The human gut hosts a diverse microbial community, essential for maintaining overall health. However, antibiotics, commonly prescribed for infections, can disrupt this delicate balance, leading to antibiotic-associated diarrhea, inflammatory bowel disease, obesity, and even neurological...

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Main Authors: Shuwei Yang, Jiaqi Qiao, Meng Zhang, Lai-Yu Kwok, Bojana Bogovič Matijašić, Heping Zhang, Wenyi Zhang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Advanced Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224002303
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Summary:Background: The human gut hosts a diverse microbial community, essential for maintaining overall health. However, antibiotics, commonly prescribed for infections, can disrupt this delicate balance, leading to antibiotic-associated diarrhea, inflammatory bowel disease, obesity, and even neurological disorders. Recognizing this, probiotics have emerged as a promising strategy to counteract these adverse effects. Aim of review: This review aims to offer a comprehensive overview of the latest evidence concerning the utilization of probiotics in managing antibiotic-associated side effects. Key scientific concepts of review: Probiotics play a crucial role in preserving gut homeostasis, regulating intestinal function and metabolism, and modulating the host immune system. These mechanisms serve to effectively alleviate antibiotic-associated adverse effects and enhance overall well-being.
ISSN:2090-1232