Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance
IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Anc...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565388/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850276317013999616 |
|---|---|
| author | Shanshan Liang Wei Xu Wei Xu Peiying Zhong Chuanmin Tao Li Zhang Chengyao Jia |
| author_facet | Shanshan Liang Wei Xu Wei Xu Peiying Zhong Chuanmin Tao Li Zhang Chengyao Jia |
| author_sort | Shanshan Liang |
| collection | DOAJ |
| description | IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Ancillary tests indicated persistent positivity of IgG4 antibody, and IgG4-RD-related ophthalmopathy was diagnosed based on the criteria. Concurrently, serum protein electrophoresis revealed an M protein level of 12.23 g/L. Immunofixation electrophoresis suggested a positive IgG λ-type M protein, and MGUS was diagnosed in conjunction with bone marrow smear and flow cytometry. |
| format | Article |
| id | doaj-art-7b142a82f3db41b48a3aa3ceca151cad |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-7b142a82f3db41b48a3aa3ceca151cad2025-08-20T01:50:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15653881565388Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significanceShanshan Liang0Wei Xu1Wei Xu2Peiying Zhong3Chuanmin Tao4Li Zhang5Chengyao Jia6Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Clinical Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaDepartment of Laboratory, 363 Hospital, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of hematology, West China hospital, Sichuan University, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, ChinaIgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Ancillary tests indicated persistent positivity of IgG4 antibody, and IgG4-RD-related ophthalmopathy was diagnosed based on the criteria. Concurrently, serum protein electrophoresis revealed an M protein level of 12.23 g/L. Immunofixation electrophoresis suggested a positive IgG λ-type M protein, and MGUS was diagnosed in conjunction with bone marrow smear and flow cytometry.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565388/fullIgG4-RD-related ophthalmopathydiagnostic criteriaM proteinIgEmonoclonal gammaglobulinemia of undetermined significance |
| spellingShingle | Shanshan Liang Wei Xu Wei Xu Peiying Zhong Chuanmin Tao Li Zhang Chengyao Jia Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance Frontiers in Immunology IgG4-RD-related ophthalmopathy diagnostic criteria M protein IgE monoclonal gammaglobulinemia of undetermined significance |
| title | Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance |
| title_full | Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance |
| title_fullStr | Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance |
| title_full_unstemmed | Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance |
| title_short | Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance |
| title_sort | case report igg4 rd related ophthalmopathy combined with monoclonal gammopathy of undetermined significance |
| topic | IgG4-RD-related ophthalmopathy diagnostic criteria M protein IgE monoclonal gammaglobulinemia of undetermined significance |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565388/full |
| work_keys_str_mv | AT shanshanliang casereportigg4rdrelatedophthalmopathycombinedwithmonoclonalgammopathyofundeterminedsignificance AT weixu casereportigg4rdrelatedophthalmopathycombinedwithmonoclonalgammopathyofundeterminedsignificance AT weixu casereportigg4rdrelatedophthalmopathycombinedwithmonoclonalgammopathyofundeterminedsignificance AT peiyingzhong casereportigg4rdrelatedophthalmopathycombinedwithmonoclonalgammopathyofundeterminedsignificance AT chuanmintao casereportigg4rdrelatedophthalmopathycombinedwithmonoclonalgammopathyofundeterminedsignificance AT lizhang casereportigg4rdrelatedophthalmopathycombinedwithmonoclonalgammopathyofundeterminedsignificance AT chengyaojia casereportigg4rdrelatedophthalmopathycombinedwithmonoclonalgammopathyofundeterminedsignificance |