Adverse Childhood Experiences and Social Participation on Frailty State Transitions among middle-aged and older adults: evidence from a 10-year prospective study in China

Objectives: Adverse childhood experiences (ACEs) are associated with frailty, while the association with frailty state transitions and the role of social participation remain unclear. This study aimed to investigate the association between ACEs and frailty state transitions, alongside the moderating...

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Main Authors: Jiajia Li, Heming Pei, Xiaojin Yan, Yue Wei, Gong Chen, Lijun Pei
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:The Journal of Nutrition, Health and Aging
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Online Access:http://www.sciencedirect.com/science/article/pii/S1279770724004883
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author Jiajia Li
Heming Pei
Xiaojin Yan
Yue Wei
Gong Chen
Lijun Pei
author_facet Jiajia Li
Heming Pei
Xiaojin Yan
Yue Wei
Gong Chen
Lijun Pei
author_sort Jiajia Li
collection DOAJ
description Objectives: Adverse childhood experiences (ACEs) are associated with frailty, while the association with frailty state transitions and the role of social participation remain unclear. This study aimed to investigate the association between ACEs and frailty state transitions, alongside the moderating effect of social participation Methods: Data from 9,621 adults aged 45 and older from the China Health and Retirement Longitudinal Study (2011–2020) were analyzed. Frailty was measured with the frailty index, while ACEs and social participation were measured with a validated questionnaire. The association between ACEs and frailty state transitions was estimated using multi-state models. An interaction analysis were used to examine the moderating effects of social participation. Results: Participants with higher ACEs scores (≥4) were associated with an increased probability of forward transition (robust to pre-frail, HR = 1.37, 95%CI: 1.21–1.54; prefrail to frail, HR = 1.39, 95%CI: 1.18–1.63) and decreased probability of backward transition (pre-frail to robust, HR = 0.64, 95%CI: 0.55–0.76). Additionally, participants with moderate and high level social participation were associated with an increased probability of backward transition (pre-frail to robust, HR = 1.11, 95%CI: 1.01–1.23; frail to pre-frail, HR = 1.17, 95%CI: 1.02–1.33, respectively). Social participation moderated the association between ACEs exposure and frailty (P for interaction <0.05), while participants with lower ACEs scores (1 and 2) and high social participation were associated with an increased probability of transition from frail to pre-frail (HR = 1.26, 95%CI: 1.04–1.89 and HR = 1.15, 95%CI: 1.08–1.69). Conclusions: High ACEs scores were associated with an increased likelihood of adverse frailty development. Older adults with ACEs exposure might benefit from intervention strategies to improve social participation.
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spelling doaj-art-7b11228095034cb78625f6a8783da6722025-08-20T02:21:06ZengElsevierThe Journal of Nutrition, Health and Aging1760-47882024-12-01281210040010.1016/j.jnha.2024.100400Adverse Childhood Experiences and Social Participation on Frailty State Transitions among middle-aged and older adults: evidence from a 10-year prospective study in ChinaJiajia Li0Heming Pei1Xiaojin Yan2Yue Wei3Gong Chen4Lijun Pei5Institute of Population Research, Peking University, Beijing, ChinaButler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, United States; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, United StatesInstitute of Population Research, Peking University, Beijing, ChinaInstitute of Population Research, Peking University, Beijing, ChinaInstitute of Population Research, Peking University, Beijing, China; Corresponding author.Institute of Population Research, Peking University, Beijing, China; Corresponding author.Objectives: Adverse childhood experiences (ACEs) are associated with frailty, while the association with frailty state transitions and the role of social participation remain unclear. This study aimed to investigate the association between ACEs and frailty state transitions, alongside the moderating effect of social participation Methods: Data from 9,621 adults aged 45 and older from the China Health and Retirement Longitudinal Study (2011–2020) were analyzed. Frailty was measured with the frailty index, while ACEs and social participation were measured with a validated questionnaire. The association between ACEs and frailty state transitions was estimated using multi-state models. An interaction analysis were used to examine the moderating effects of social participation. Results: Participants with higher ACEs scores (≥4) were associated with an increased probability of forward transition (robust to pre-frail, HR = 1.37, 95%CI: 1.21–1.54; prefrail to frail, HR = 1.39, 95%CI: 1.18–1.63) and decreased probability of backward transition (pre-frail to robust, HR = 0.64, 95%CI: 0.55–0.76). Additionally, participants with moderate and high level social participation were associated with an increased probability of backward transition (pre-frail to robust, HR = 1.11, 95%CI: 1.01–1.23; frail to pre-frail, HR = 1.17, 95%CI: 1.02–1.33, respectively). Social participation moderated the association between ACEs exposure and frailty (P for interaction <0.05), while participants with lower ACEs scores (1 and 2) and high social participation were associated with an increased probability of transition from frail to pre-frail (HR = 1.26, 95%CI: 1.04–1.89 and HR = 1.15, 95%CI: 1.08–1.69). Conclusions: High ACEs scores were associated with an increased likelihood of adverse frailty development. Older adults with ACEs exposure might benefit from intervention strategies to improve social participation.http://www.sciencedirect.com/science/article/pii/S1279770724004883FrailtyACEsSocial participationMulti-state model
spellingShingle Jiajia Li
Heming Pei
Xiaojin Yan
Yue Wei
Gong Chen
Lijun Pei
Adverse Childhood Experiences and Social Participation on Frailty State Transitions among middle-aged and older adults: evidence from a 10-year prospective study in China
The Journal of Nutrition, Health and Aging
Frailty
ACEs
Social participation
Multi-state model
title Adverse Childhood Experiences and Social Participation on Frailty State Transitions among middle-aged and older adults: evidence from a 10-year prospective study in China
title_full Adverse Childhood Experiences and Social Participation on Frailty State Transitions among middle-aged and older adults: evidence from a 10-year prospective study in China
title_fullStr Adverse Childhood Experiences and Social Participation on Frailty State Transitions among middle-aged and older adults: evidence from a 10-year prospective study in China
title_full_unstemmed Adverse Childhood Experiences and Social Participation on Frailty State Transitions among middle-aged and older adults: evidence from a 10-year prospective study in China
title_short Adverse Childhood Experiences and Social Participation on Frailty State Transitions among middle-aged and older adults: evidence from a 10-year prospective study in China
title_sort adverse childhood experiences and social participation on frailty state transitions among middle aged and older adults evidence from a 10 year prospective study in china
topic Frailty
ACEs
Social participation
Multi-state model
url http://www.sciencedirect.com/science/article/pii/S1279770724004883
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