Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure
We report a case of severe acute kidney failure due to crescentic glomerulonephritis who presented initially with culture-negative endocarditis with vegetations on the aortic valve. Anti-nuclear and anti-phospholipid antibodies were positive with initially negative anti-neutrophil cytoplasmic antibo...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2021/9951264 |
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| author | Ramanath Dukkipati Benjamin Lawson Cynthia C. Nast Anuja Shah |
| author_facet | Ramanath Dukkipati Benjamin Lawson Cynthia C. Nast Anuja Shah |
| author_sort | Ramanath Dukkipati |
| collection | DOAJ |
| description | We report a case of severe acute kidney failure due to crescentic glomerulonephritis who presented initially with culture-negative endocarditis with vegetations on the aortic valve. Anti-nuclear and anti-phospholipid antibodies were positive with initially negative anti-neutrophil cytoplasmic antibodies (ANCAs). Kidney biopsy revealed severe acute crescentic glomerulonephritis with mesangial immune complex deposition. PR3-ANCA subsequently become positive, and the patient developed worsening kidney failure requiring hemodialysis. This case illustrates that Bartonella can present as culture-negative endocarditis with severe crescentic glomerulonephritis with positive PR-3 ANCAs and can mimic ANCA-associated crescentic glomerulonephritis. |
| format | Article |
| id | doaj-art-7b0eec508f9340d6ad76942046bb617c |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-7b0eec508f9340d6ad76942046bb617c2025-08-20T03:35:03ZengWileyCase Reports in Nephrology2090-66412090-665X2021-01-01202110.1155/2021/99512649951264Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal FailureRamanath Dukkipati0Benjamin Lawson1Cynthia C. Nast2Anuja Shah3Harbor-UCLA Medical Center, Torrance, California, USAHarbor-UCLA Medical Center, Torrance, California, USACedars-Sinai Medical Center, Los Angeles, California, USAHarbor-UCLA Medical Center, Torrance, California, USAWe report a case of severe acute kidney failure due to crescentic glomerulonephritis who presented initially with culture-negative endocarditis with vegetations on the aortic valve. Anti-nuclear and anti-phospholipid antibodies were positive with initially negative anti-neutrophil cytoplasmic antibodies (ANCAs). Kidney biopsy revealed severe acute crescentic glomerulonephritis with mesangial immune complex deposition. PR3-ANCA subsequently become positive, and the patient developed worsening kidney failure requiring hemodialysis. This case illustrates that Bartonella can present as culture-negative endocarditis with severe crescentic glomerulonephritis with positive PR-3 ANCAs and can mimic ANCA-associated crescentic glomerulonephritis.http://dx.doi.org/10.1155/2021/9951264 |
| spellingShingle | Ramanath Dukkipati Benjamin Lawson Cynthia C. Nast Anuja Shah Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure Case Reports in Nephrology |
| title | Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure |
| title_full | Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure |
| title_fullStr | Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure |
| title_full_unstemmed | Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure |
| title_short | Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure |
| title_sort | bartonella associated endocarditis with severe active crescentic glomerulonephritis and acute renal failure |
| url | http://dx.doi.org/10.1155/2021/9951264 |
| work_keys_str_mv | AT ramanathdukkipati bartonellaassociatedendocarditiswithsevereactivecrescenticglomerulonephritisandacuterenalfailure AT benjaminlawson bartonellaassociatedendocarditiswithsevereactivecrescenticglomerulonephritisandacuterenalfailure AT cynthiacnast bartonellaassociatedendocarditiswithsevereactivecrescenticglomerulonephritisandacuterenalfailure AT anujashah bartonellaassociatedendocarditiswithsevereactivecrescenticglomerulonephritisandacuterenalfailure |