LED light treatments enhance neuroprotective properties and differentially impact phenolic compounds and triterpenoid content in Gotu Kola (Centella asiatica (L.) Urb.)
Due to an array of medicinal properties being attributed to Gotu kola (Centella asiatica (L.) Urb.), there is a growing demand for the incorporation of the plant as an herbal ingredient in drugs, cosmetics but mainly in dietary supplements and herbal drugs, which has been causing a gradual decline o...
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Elsevier
2024-12-01
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| Series: | Current Plant Biology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214662824000689 |
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| author | Melissa Soun-udom Maria Rita Garcia Andreia P. Oliveira Paula B. Andrade Srunya Vajrodaya Sutsawat Duangsrisai Nelson G.M. Gomes |
| author_facet | Melissa Soun-udom Maria Rita Garcia Andreia P. Oliveira Paula B. Andrade Srunya Vajrodaya Sutsawat Duangsrisai Nelson G.M. Gomes |
| author_sort | Melissa Soun-udom |
| collection | DOAJ |
| description | Due to an array of medicinal properties being attributed to Gotu kola (Centella asiatica (L.) Urb.), there is a growing demand for the incorporation of the plant as an herbal ingredient in drugs, cosmetics but mainly in dietary supplements and herbal drugs, which has been causing a gradual decline on its wild population. A possible way might be the improvement of the content in bioactive constituents that, in this specific matter, have been mainly labelled as being pentacyclic triterpenoids. We hypothesize that using light-emitting diode (LED) treatments can enhance its content in bioactives and improve its neuroprotective effects. Specific LED light treatments caused a metabolic shift, globally reducing the concentrations of the triterpenoids madecassoside, asiaticoside, and their corresponding aglycones. However, LED light treatments caused a pronounced increase in specific phenolic bioactives in comparison with samples obtained under sunlight, mostly pronounced in the concentrations of di-O-caffeoylquinic acids. Principal component analysis corroborated that the improvement on the neuroinflammatory status in BV-2 microglial cells and enhanced inhibition of tyrosinase are correlated with the increase in specific phenolic constituents resulting from LED light treatments. While the anti-neuroinflammatory effects in BV-2 microglial cells are demonstrated here for the first time, our core findings are mostly crucial for meeting the increased demand for C. asiatica in herbal products, as our LED light treatment boosts yields in specific phenolic bioactives and improves neuroprotective effects. |
| format | Article |
| id | doaj-art-7b0dcc8944e046939cc61685a8a0093e |
| institution | OA Journals |
| issn | 2214-6628 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Plant Biology |
| spelling | doaj-art-7b0dcc8944e046939cc61685a8a0093e2025-08-20T02:34:19ZengElsevierCurrent Plant Biology2214-66282024-12-014010038610.1016/j.cpb.2024.100386LED light treatments enhance neuroprotective properties and differentially impact phenolic compounds and triterpenoid content in Gotu Kola (Centella asiatica (L.) Urb.)Melissa Soun-udom0Maria Rita Garcia1Andreia P. Oliveira2Paula B. Andrade3Srunya Vajrodaya4Sutsawat Duangsrisai5Nelson G.M. Gomes6Department of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wan Road, Chatuchak, Bangkok 10900, ThailandREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, Porto 4050-313, Portugal; 1H-TOXRUN - Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, Gandra 4585-116, Portugal; UCIBIO/REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, R. Jorge Viterbo Ferreira, No 228, Porto 4050-313, PortugalREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, Porto 4050-313, PortugalREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, Porto 4050-313, PortugalDepartment of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wan Road, Chatuchak, Bangkok 10900, ThailandDepartment of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wan Road, Chatuchak, Bangkok 10900, Thailand; Corresponding authors.REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, nº 228, Porto 4050-313, Portugal; Corresponding authors.Due to an array of medicinal properties being attributed to Gotu kola (Centella asiatica (L.) Urb.), there is a growing demand for the incorporation of the plant as an herbal ingredient in drugs, cosmetics but mainly in dietary supplements and herbal drugs, which has been causing a gradual decline on its wild population. A possible way might be the improvement of the content in bioactive constituents that, in this specific matter, have been mainly labelled as being pentacyclic triterpenoids. We hypothesize that using light-emitting diode (LED) treatments can enhance its content in bioactives and improve its neuroprotective effects. Specific LED light treatments caused a metabolic shift, globally reducing the concentrations of the triterpenoids madecassoside, asiaticoside, and their corresponding aglycones. However, LED light treatments caused a pronounced increase in specific phenolic bioactives in comparison with samples obtained under sunlight, mostly pronounced in the concentrations of di-O-caffeoylquinic acids. Principal component analysis corroborated that the improvement on the neuroinflammatory status in BV-2 microglial cells and enhanced inhibition of tyrosinase are correlated with the increase in specific phenolic constituents resulting from LED light treatments. While the anti-neuroinflammatory effects in BV-2 microglial cells are demonstrated here for the first time, our core findings are mostly crucial for meeting the increased demand for C. asiatica in herbal products, as our LED light treatment boosts yields in specific phenolic bioactives and improves neuroprotective effects.http://www.sciencedirect.com/science/article/pii/S2214662824000689Asiatic acidAsiatic pennywortBiosynthetic switchChlorogenic acidLight modulationMadecassic acid |
| spellingShingle | Melissa Soun-udom Maria Rita Garcia Andreia P. Oliveira Paula B. Andrade Srunya Vajrodaya Sutsawat Duangsrisai Nelson G.M. Gomes LED light treatments enhance neuroprotective properties and differentially impact phenolic compounds and triterpenoid content in Gotu Kola (Centella asiatica (L.) Urb.) Current Plant Biology Asiatic acid Asiatic pennywort Biosynthetic switch Chlorogenic acid Light modulation Madecassic acid |
| title | LED light treatments enhance neuroprotective properties and differentially impact phenolic compounds and triterpenoid content in Gotu Kola (Centella asiatica (L.) Urb.) |
| title_full | LED light treatments enhance neuroprotective properties and differentially impact phenolic compounds and triterpenoid content in Gotu Kola (Centella asiatica (L.) Urb.) |
| title_fullStr | LED light treatments enhance neuroprotective properties and differentially impact phenolic compounds and triterpenoid content in Gotu Kola (Centella asiatica (L.) Urb.) |
| title_full_unstemmed | LED light treatments enhance neuroprotective properties and differentially impact phenolic compounds and triterpenoid content in Gotu Kola (Centella asiatica (L.) Urb.) |
| title_short | LED light treatments enhance neuroprotective properties and differentially impact phenolic compounds and triterpenoid content in Gotu Kola (Centella asiatica (L.) Urb.) |
| title_sort | led light treatments enhance neuroprotective properties and differentially impact phenolic compounds and triterpenoid content in gotu kola centella asiatica l urb |
| topic | Asiatic acid Asiatic pennywort Biosynthetic switch Chlorogenic acid Light modulation Madecassic acid |
| url | http://www.sciencedirect.com/science/article/pii/S2214662824000689 |
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