HIV-associated hematologic malignancies: Experience from a Tertiary Cancer Center in India
Context and Aim: Data on HIV associated hematologic malignancies is sparse from India. This study attempts to analyze the spectrum and features of this disease at a tertiary cancer center in India. Setting and Methods: Retrospective study from case records of patients registered with a diagnosis of...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2016-01-01
|
| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2016;volume=37;issue=3;spage=141;epage=145;aulast=Reddy |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850250799834202112 |
|---|---|
| author | Rakesh Reddy Ajay Gogia Lalit Kumar Atul Sharma Sameer Bakhshi Mehar C Sharma Saumyaranjan Mallick Ranjit Sahoo |
| author_facet | Rakesh Reddy Ajay Gogia Lalit Kumar Atul Sharma Sameer Bakhshi Mehar C Sharma Saumyaranjan Mallick Ranjit Sahoo |
| author_sort | Rakesh Reddy |
| collection | DOAJ |
| description | Context and Aim: Data on HIV associated hematologic malignancies is sparse from India. This study attempts to analyze the spectrum and features of this disease at a tertiary cancer center in India. Setting and Methods: Retrospective study from case records of patients registered with a diagnosis of hematologic malignancy and HIV infection between January 2010 and June 2015. Results: Thirteen cases of HIV associated hematologic malignancies were identified, six of them pediatric. HIV diagnosis was concurrent to diagnosis of cancer in 12 and preceded it in one of them. ECOG PS at presentation was >1 in all of them. All patients, except one, had B symptoms. Six of the patients had bulky disease and six are stage 4. Predominant extranodal disease was seen in 67% of them. NHL accounted for 10 of 13 patients and DLBCL-Germinal center was the most common subtype. Mean CD4+ cell count was 235/μL (range, 32-494). HAART could be given along with chemotherapy to 11 patients. Two-thirds of patients received standard doses of therapy. Chemo-toxicity required hospitalization in 58%. CR was achieved in 45% and 36% had progressive disease with first-line therapy. At the time of last follow up, 3 patients were alive with responsive disease, 2 in CR and 1 in PR. None of the pediatric patients were long time responders. Conclusions: These malignancies were of advanced stage and higher grade. Goal of therapy, in the HAART era, is curative. Pediatric patients had dismal outcome despite good chemotherapy and HAART. There is an urgent need to improve data collection for HIV related cancers in India. |
| format | Article |
| id | doaj-art-7b0d0738a4d04d71a23cb3da6a82b5aa |
| institution | OA Journals |
| issn | 0971-5851 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-7b0d0738a4d04d71a23cb3da6a82b5aa2025-08-20T01:58:05ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512016-01-0137314114510.4103/0971-5851.190355HIV-associated hematologic malignancies: Experience from a Tertiary Cancer Center in IndiaRakesh ReddyAjay GogiaLalit KumarAtul SharmaSameer BakhshiMehar C SharmaSaumyaranjan MallickRanjit SahooContext and Aim: Data on HIV associated hematologic malignancies is sparse from India. This study attempts to analyze the spectrum and features of this disease at a tertiary cancer center in India. Setting and Methods: Retrospective study from case records of patients registered with a diagnosis of hematologic malignancy and HIV infection between January 2010 and June 2015. Results: Thirteen cases of HIV associated hematologic malignancies were identified, six of them pediatric. HIV diagnosis was concurrent to diagnosis of cancer in 12 and preceded it in one of them. ECOG PS at presentation was >1 in all of them. All patients, except one, had B symptoms. Six of the patients had bulky disease and six are stage 4. Predominant extranodal disease was seen in 67% of them. NHL accounted for 10 of 13 patients and DLBCL-Germinal center was the most common subtype. Mean CD4+ cell count was 235/μL (range, 32-494). HAART could be given along with chemotherapy to 11 patients. Two-thirds of patients received standard doses of therapy. Chemo-toxicity required hospitalization in 58%. CR was achieved in 45% and 36% had progressive disease with first-line therapy. At the time of last follow up, 3 patients were alive with responsive disease, 2 in CR and 1 in PR. None of the pediatric patients were long time responders. Conclusions: These malignancies were of advanced stage and higher grade. Goal of therapy, in the HAART era, is curative. Pediatric patients had dismal outcome despite good chemotherapy and HAART. There is an urgent need to improve data collection for HIV related cancers in India.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2016;volume=37;issue=3;spage=141;epage=145;aulast=ReddyAIDS-related lymphomadiffuse large B-cell lymphomahighly active anti-retroviral therapyHIV-related cancer in Indiapediatric HIV malignancies |
| spellingShingle | Rakesh Reddy Ajay Gogia Lalit Kumar Atul Sharma Sameer Bakhshi Mehar C Sharma Saumyaranjan Mallick Ranjit Sahoo HIV-associated hematologic malignancies: Experience from a Tertiary Cancer Center in India Indian Journal of Medical and Paediatric Oncology AIDS-related lymphoma diffuse large B-cell lymphoma highly active anti-retroviral therapy HIV-related cancer in India pediatric HIV malignancies |
| title | HIV-associated hematologic malignancies: Experience from a Tertiary Cancer Center in India |
| title_full | HIV-associated hematologic malignancies: Experience from a Tertiary Cancer Center in India |
| title_fullStr | HIV-associated hematologic malignancies: Experience from a Tertiary Cancer Center in India |
| title_full_unstemmed | HIV-associated hematologic malignancies: Experience from a Tertiary Cancer Center in India |
| title_short | HIV-associated hematologic malignancies: Experience from a Tertiary Cancer Center in India |
| title_sort | hiv associated hematologic malignancies experience from a tertiary cancer center in india |
| topic | AIDS-related lymphoma diffuse large B-cell lymphoma highly active anti-retroviral therapy HIV-related cancer in India pediatric HIV malignancies |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2016;volume=37;issue=3;spage=141;epage=145;aulast=Reddy |
| work_keys_str_mv | AT rakeshreddy hivassociatedhematologicmalignanciesexperiencefromatertiarycancercenterinindia AT ajaygogia hivassociatedhematologicmalignanciesexperiencefromatertiarycancercenterinindia AT lalitkumar hivassociatedhematologicmalignanciesexperiencefromatertiarycancercenterinindia AT atulsharma hivassociatedhematologicmalignanciesexperiencefromatertiarycancercenterinindia AT sameerbakhshi hivassociatedhematologicmalignanciesexperiencefromatertiarycancercenterinindia AT meharcsharma hivassociatedhematologicmalignanciesexperiencefromatertiarycancercenterinindia AT saumyaranjanmallick hivassociatedhematologicmalignanciesexperiencefromatertiarycancercenterinindia AT ranjitsahoo hivassociatedhematologicmalignanciesexperiencefromatertiarycancercenterinindia |