Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive Hepatitis
The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation ofthe immune system, in patients with histologically verified chronic active hepatitis associated to hepatitis C virus infection, with those in...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000256 |
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| _version_ | 1832553067187273728 |
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| author | C. Caruso G. Candore D. Cigna S. Tripi G. Di Gaetano G. Migneco G. Montalto I. Ruggieri A. Notarbartolo |
| author_facet | C. Caruso G. Candore D. Cigna S. Tripi G. Di Gaetano G. Migneco G. Montalto I. Ruggieri A. Notarbartolo |
| author_sort | C. Caruso |
| collection | DOAJ |
| description | The aim of the present study was to compare serum levels of soluble
forms of interleukin-2 receptor, CD4 and CD8, released by
lymphocytes during activation ofthe immune system, in patients with
histologically verified chronic active hepatitis associated to
hepatitis C virus infection, with those in healthy subjects.
Significantly higher levels of soluble IL-2R and soluble CD8 were
found in patients with chronic active hepatitis compared with
controls. In contrast no difference was found for soluble CD4 values
in the two groups. No correlations were found for both sIL-2R and
sCD8 and these two molecules with other parameters of liver
function. These results indicate that in these patients there is a
general activation of the immune system, but the lack of correlation
with parameters of liver function strengthens the suggestion that
this activation does not play a role in the pathogenesis of chronic
type C hepatitis. |
| format | Article |
| id | doaj-art-7b09e797d84c4dfc8148107b74f30b73 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-7b09e797d84c4dfc8148107b74f30b732025-02-03T05:57:09ZengWileyMediators of Inflammation0962-93511466-18611994-01-013318518710.1155/S0962935194000256Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive HepatitisC. Caruso0G. Candore1D. Cigna2S. Tripi3G. Di Gaetano4G. Migneco5G. Montalto6I. Ruggieri7A. Notarbartolo8Istituto di Patologia generale, Università di Palermo, Corso Tukory 211, Palermo 90134, ItalyIstituto di Patologia generale, Università di Palermo, Corso Tukory 211, Palermo 90134, ItalyIstituto di Patologia generale, Università di Palermo, Corso Tukory 211, Palermo 90134, ItalyIstituto di Clinica Medica e Terapia Medica, Università di Palermo, Via del Vespro, Palermo 90100, ItalyIstituto di Clinica Medica e Terapia Medica, Università di Palermo, Via del Vespro, Palermo 90100, ItalyIstituto di Clinica Medica e Terapia Medica, Università di Palermo, Via del Vespro, Palermo 90100, ItalyIstituto di Medicina Interna e Geriatria, Università di Palermo, Via del Vespro, Palermo 90100, ItalyIstituto di Medicina Interna e Geriatria, Università di Palermo, Via del Vespro, Palermo 90100, ItalyIstituto di Medicina Interna e Geriatria, Università di Palermo, Via del Vespro, Palermo 90100, ItalyThe aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation ofthe immune system, in patients with histologically verified chronic active hepatitis associated to hepatitis C virus infection, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD8 were found in patients with chronic active hepatitis compared with controls. In contrast no difference was found for soluble CD4 values in the two groups. No correlations were found for both sIL-2R and sCD8 and these two molecules with other parameters of liver function. These results indicate that in these patients there is a general activation of the immune system, but the lack of correlation with parameters of liver function strengthens the suggestion that this activation does not play a role in the pathogenesis of chronic type C hepatitis.http://dx.doi.org/10.1155/S0962935194000256 |
| spellingShingle | C. Caruso G. Candore D. Cigna S. Tripi G. Di Gaetano G. Migneco G. Montalto I. Ruggieri A. Notarbartolo Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive Hepatitis Mediators of Inflammation |
| title | Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive Hepatitis |
| title_full | Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive Hepatitis |
| title_fullStr | Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive Hepatitis |
| title_full_unstemmed | Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive Hepatitis |
| title_short | Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive Hepatitis |
| title_sort | serum levels of soluble il 2r cd4 and cd8 in chronic active hcv positive hepatitis |
| url | http://dx.doi.org/10.1155/S0962935194000256 |
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