Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis
Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterizat...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2022/1132544 |
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| _version_ | 1832562613222899712 |
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| author | Maryam Mehdipour Dalivand Parastou Tizro Julie Partain Anita Aggarwal Jack Lichy Francisco Mot Ara Victor E. Nava |
| author_facet | Maryam Mehdipour Dalivand Parastou Tizro Julie Partain Anita Aggarwal Jack Lichy Francisco Mot Ara Victor E. Nava |
| author_sort | Maryam Mehdipour Dalivand |
| collection | DOAJ |
| description | Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterization revealed an unusual MPL (T487I) point mutation and unmutated VH4-39. After nonstandard chemotherapy, the patient remains in morphologic remission. These findings may stimulate further research to clarify the pathogenesis of hematologic neoplasms. |
| format | Article |
| id | doaj-art-7b0840f9ddf247b79d51b459d837c473 |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-7b0840f9ddf247b79d51b459d837c4732025-02-03T01:22:13ZengWileyCase Reports in Hematology2090-65792022-01-01202210.1155/2022/1132544Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular AnalysisMaryam Mehdipour Dalivand0Parastou Tizro1Julie Partain2Anita Aggarwal3Jack Lichy4Francisco Mot Ara5Victor E. Nava6The George Washington UniversityThe George Washington UniversityOregon Health and Science UniversityThe George Washington UniversityThe George Washington UniversityHospital J.M. de Los RiosThe George Washington UniversityAlthough acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterization revealed an unusual MPL (T487I) point mutation and unmutated VH4-39. After nonstandard chemotherapy, the patient remains in morphologic remission. These findings may stimulate further research to clarify the pathogenesis of hematologic neoplasms.http://dx.doi.org/10.1155/2022/1132544 |
| spellingShingle | Maryam Mehdipour Dalivand Parastou Tizro Julie Partain Anita Aggarwal Jack Lichy Francisco Mot Ara Victor E. Nava Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis Case Reports in Hematology |
| title | Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis |
| title_full | Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis |
| title_fullStr | Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis |
| title_full_unstemmed | Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis |
| title_short | Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis |
| title_sort | concurrent b cell acute lymphoblastic lymphoma leukemia and monoclonal b cell lymphocytosis a case report with extensive molecular analysis |
| url | http://dx.doi.org/10.1155/2022/1132544 |
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