Mitochondrial-related drug resistance lncRNAs as prognostic biomarkers in laryngeal squamous cell carcinoma
Abstract Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck that significantly impacts patients' quality of life, with chemotherapy resistance notably affecting prognosis. This study aims to identify prognostic biomarkers to optimize treatment strategies f...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2024-12-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-024-01690-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850253835379933184 |
|---|---|
| author | Zhimin Wu Yi Chen Dizhi Jiang Yipeng Pan Tuoxian Tang Yifei Ma Tiannake Shapaer |
| author_facet | Zhimin Wu Yi Chen Dizhi Jiang Yipeng Pan Tuoxian Tang Yifei Ma Tiannake Shapaer |
| author_sort | Zhimin Wu |
| collection | DOAJ |
| description | Abstract Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck that significantly impacts patients' quality of life, with chemotherapy resistance notably affecting prognosis. This study aims to identify prognostic biomarkers to optimize treatment strategies for LSCC. Using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), combined with mitochondrial gene database analysis, we identified mitochondrial lncRNAs associated with drug resistance genes. Key long non-coding RNAs (lncRNAs) were selected through univariate Cox regression and Lasso regression, and a multivariate Cox regression model was constructed to predict prognosis. We further analyzed the differences in immune function and biological pathway enrichment between high- and low-risk groups, developed a nomogram, and compared drug sensitivity. Results showed that the prognostic model based on seven mitochondrial lncRNAs could serve as an independent prognostic factor, with Area Under the Curve (AUC) values of 0.746, 0.827, and 0.771 at 1, 3, and 5 years, respectively, outperforming some existing models, demonstrating high predictive performance. Significant differences were observed in immune function and drug sensitivity between the high- and low-risk groups. The risk prediction model incorporating seven drug resistance-related mitochondrial lncRNAs can accurately and independently predict the prognosis of LSCC patients. |
| format | Article |
| id | doaj-art-7b070fbedc1246ea8945a2288f8aa077 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-7b070fbedc1246ea8945a2288f8aa0772025-08-20T01:57:16ZengSpringerDiscover Oncology2730-60112024-12-0115112010.1007/s12672-024-01690-xMitochondrial-related drug resistance lncRNAs as prognostic biomarkers in laryngeal squamous cell carcinomaZhimin Wu0Yi Chen1Dizhi Jiang2Yipeng Pan3Tuoxian Tang4Yifei Ma5Tiannake Shapaer6Department of Otorhinolaryngology Head and Neck Surgery, The Maternal and Child Health Care Hospital of Guizhou Medical UniversityDepartment of Breast and Thyroid Surgery, the Affiliated Cancer Hospital of Xinjiang Medical UniversityDepartment of Radiation Oncology, Cheeloo College of Medicine, Qilu Hospital of Shandong University, Shandong UniversityDepartment of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineDepartment of Biology, University of PennsylvaniaDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Guizhou Medical UniversityDepartment of Gastrointestinal Surgery, the Affiliated Cancer Hospital of Xinjiang Medical UniversityAbstract Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck that significantly impacts patients' quality of life, with chemotherapy resistance notably affecting prognosis. This study aims to identify prognostic biomarkers to optimize treatment strategies for LSCC. Using data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), combined with mitochondrial gene database analysis, we identified mitochondrial lncRNAs associated with drug resistance genes. Key long non-coding RNAs (lncRNAs) were selected through univariate Cox regression and Lasso regression, and a multivariate Cox regression model was constructed to predict prognosis. We further analyzed the differences in immune function and biological pathway enrichment between high- and low-risk groups, developed a nomogram, and compared drug sensitivity. Results showed that the prognostic model based on seven mitochondrial lncRNAs could serve as an independent prognostic factor, with Area Under the Curve (AUC) values of 0.746, 0.827, and 0.771 at 1, 3, and 5 years, respectively, outperforming some existing models, demonstrating high predictive performance. Significant differences were observed in immune function and drug sensitivity between the high- and low-risk groups. The risk prediction model incorporating seven drug resistance-related mitochondrial lncRNAs can accurately and independently predict the prognosis of LSCC patients.https://doi.org/10.1007/s12672-024-01690-xLaryngeal squamous cell carcinomaMitochondria-associated lncRNAsChemotherapy resistanceImmune responsePrognostic model |
| spellingShingle | Zhimin Wu Yi Chen Dizhi Jiang Yipeng Pan Tuoxian Tang Yifei Ma Tiannake Shapaer Mitochondrial-related drug resistance lncRNAs as prognostic biomarkers in laryngeal squamous cell carcinoma Discover Oncology Laryngeal squamous cell carcinoma Mitochondria-associated lncRNAs Chemotherapy resistance Immune response Prognostic model |
| title | Mitochondrial-related drug resistance lncRNAs as prognostic biomarkers in laryngeal squamous cell carcinoma |
| title_full | Mitochondrial-related drug resistance lncRNAs as prognostic biomarkers in laryngeal squamous cell carcinoma |
| title_fullStr | Mitochondrial-related drug resistance lncRNAs as prognostic biomarkers in laryngeal squamous cell carcinoma |
| title_full_unstemmed | Mitochondrial-related drug resistance lncRNAs as prognostic biomarkers in laryngeal squamous cell carcinoma |
| title_short | Mitochondrial-related drug resistance lncRNAs as prognostic biomarkers in laryngeal squamous cell carcinoma |
| title_sort | mitochondrial related drug resistance lncrnas as prognostic biomarkers in laryngeal squamous cell carcinoma |
| topic | Laryngeal squamous cell carcinoma Mitochondria-associated lncRNAs Chemotherapy resistance Immune response Prognostic model |
| url | https://doi.org/10.1007/s12672-024-01690-x |
| work_keys_str_mv | AT zhiminwu mitochondrialrelateddrugresistancelncrnasasprognosticbiomarkersinlaryngealsquamouscellcarcinoma AT yichen mitochondrialrelateddrugresistancelncrnasasprognosticbiomarkersinlaryngealsquamouscellcarcinoma AT dizhijiang mitochondrialrelateddrugresistancelncrnasasprognosticbiomarkersinlaryngealsquamouscellcarcinoma AT yipengpan mitochondrialrelateddrugresistancelncrnasasprognosticbiomarkersinlaryngealsquamouscellcarcinoma AT tuoxiantang mitochondrialrelateddrugresistancelncrnasasprognosticbiomarkersinlaryngealsquamouscellcarcinoma AT yifeima mitochondrialrelateddrugresistancelncrnasasprognosticbiomarkersinlaryngealsquamouscellcarcinoma AT tiannakeshapaer mitochondrialrelateddrugresistancelncrnasasprognosticbiomarkersinlaryngealsquamouscellcarcinoma |