A Pilot Study of Quantitative MRI Measurements of Ventricular Volume and Cortical Atrophy for the Differential Diagnosis of Normal Pressure Hydrocephalus
Current radiologic diagnosis of normal pressure hydrocephalus (NPH) requires a subjective judgment of whether lateral ventricular enlargement is disproportionate to cerebral atrophy based on visual inspection of brain images. We investigated whether quantitative measurements of lateral ventricular v...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/718150 |
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| author | Dana W. Moore Ilhami Kovanlikaya Linda A. Heier Ashish Raj Chaorui Huang King-Wai Chu Norman R. Relkin |
| author_facet | Dana W. Moore Ilhami Kovanlikaya Linda A. Heier Ashish Raj Chaorui Huang King-Wai Chu Norman R. Relkin |
| author_sort | Dana W. Moore |
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| description | Current radiologic diagnosis of normal pressure hydrocephalus (NPH) requires a subjective judgment of whether lateral ventricular enlargement is disproportionate to cerebral atrophy based on visual inspection of brain images. We investigated whether quantitative measurements of lateral ventricular volume and total cortical thickness (a correlate of cerebral atrophy) could be used to more objectively distinguish NPH from normal controls (NC), Alzheimer's (AD), and Parkinson's disease (PD). Volumetric MRIs were obtained prospectively from patients with NPH (n=5), PD (n=5), and NC (5). Additional NC (n=5) and AD patients (n=10) from the ADNI cohort were examined. Although mean ventricular volume was significantly greater in the NPH group than all others, the range of values overlapped those of the AD group. Individuals with NPH could be better distinguished when ventricular volume and total cortical thickness were considered in combination. This pilot study suggests that volumetric MRI measurements hold promise for improving NPH differential diagnosis. |
| format | Article |
| id | doaj-art-7aff0447b01a4287ab3d4c1ec8a7ec95 |
| institution | OA Journals |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-7aff0447b01a4287ab3d4c1ec8a7ec952025-08-20T02:07:02ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/718150718150A Pilot Study of Quantitative MRI Measurements of Ventricular Volume and Cortical Atrophy for the Differential Diagnosis of Normal Pressure HydrocephalusDana W. Moore0Ilhami Kovanlikaya1Linda A. Heier2Ashish Raj3Chaorui Huang4King-Wai Chu5Norman R. Relkin6Department of Neurology and Neuroscience, Weill Cornell Medical College, 428 East 72nd Street, Suite 500, New York, NY 10021, USADepartment of Radiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USADepartment of Radiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USADepartment of Radiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USADepartment of Neurology and Neuroscience, Weill Cornell Medical College, 428 East 72nd Street, Suite 500, New York, NY 10021, USAMental Illness Research, Education, and Clinical Center, James J. Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USADepartment of Neurology and Neuroscience, Weill Cornell Medical College, 428 East 72nd Street, Suite 500, New York, NY 10021, USACurrent radiologic diagnosis of normal pressure hydrocephalus (NPH) requires a subjective judgment of whether lateral ventricular enlargement is disproportionate to cerebral atrophy based on visual inspection of brain images. We investigated whether quantitative measurements of lateral ventricular volume and total cortical thickness (a correlate of cerebral atrophy) could be used to more objectively distinguish NPH from normal controls (NC), Alzheimer's (AD), and Parkinson's disease (PD). Volumetric MRIs were obtained prospectively from patients with NPH (n=5), PD (n=5), and NC (5). Additional NC (n=5) and AD patients (n=10) from the ADNI cohort were examined. Although mean ventricular volume was significantly greater in the NPH group than all others, the range of values overlapped those of the AD group. Individuals with NPH could be better distinguished when ventricular volume and total cortical thickness were considered in combination. This pilot study suggests that volumetric MRI measurements hold promise for improving NPH differential diagnosis.http://dx.doi.org/10.1155/2012/718150 |
| spellingShingle | Dana W. Moore Ilhami Kovanlikaya Linda A. Heier Ashish Raj Chaorui Huang King-Wai Chu Norman R. Relkin A Pilot Study of Quantitative MRI Measurements of Ventricular Volume and Cortical Atrophy for the Differential Diagnosis of Normal Pressure Hydrocephalus Neurology Research International |
| title | A Pilot Study of Quantitative MRI Measurements of Ventricular Volume and Cortical Atrophy for the Differential Diagnosis of Normal Pressure Hydrocephalus |
| title_full | A Pilot Study of Quantitative MRI Measurements of Ventricular Volume and Cortical Atrophy for the Differential Diagnosis of Normal Pressure Hydrocephalus |
| title_fullStr | A Pilot Study of Quantitative MRI Measurements of Ventricular Volume and Cortical Atrophy for the Differential Diagnosis of Normal Pressure Hydrocephalus |
| title_full_unstemmed | A Pilot Study of Quantitative MRI Measurements of Ventricular Volume and Cortical Atrophy for the Differential Diagnosis of Normal Pressure Hydrocephalus |
| title_short | A Pilot Study of Quantitative MRI Measurements of Ventricular Volume and Cortical Atrophy for the Differential Diagnosis of Normal Pressure Hydrocephalus |
| title_sort | pilot study of quantitative mri measurements of ventricular volume and cortical atrophy for the differential diagnosis of normal pressure hydrocephalus |
| url | http://dx.doi.org/10.1155/2012/718150 |
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