Impact of mutations in immunodominant regions of SARS-CoV-2 variants on recognition by CD8+ T cell: An in silico analysis

Impact of mutations in immunodominant regions of SARS-CoV-2 variants on recognition by CD8+ T cell: An in silico analysis

Background: This study aimed to investigate whether mutations in the immunodominant regions of the S, M, and N proteins of the Gamma, Delta, and Omicron SARS-CoV-2 variants that circulated in Brazil affect the recognition of viral antigens by Brazilian HLA-I-restricted CD8+ T cell epitopes, using an...

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Main Authors: Greice Carolina Santos da Silva, Victoria Cruz Paraná, Filipe Ferreira de Almeida Rego, Mariana Maciel Portela, Mariana Barros Queiroz, Raimundo Coutinho Junior, Carlos Gustavo Regis da Silva, Luana Leandro Gois, Maria Fernanda Rios Grassi
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Journal of Infection and Public Health
Subjects:
SARS-CoV-2
Variants of concern
Immunodominant region
CD8 T epitopes
In silico
Computational analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S1876034125001522
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