Circulating mucosa-associated invariant T cells are decreased and have impaired function in patients with diffuse large B-cell lymphoma
Mucosa-associated invariant T (MAIT) cells are associated with tumor immunity. However, their role in diffuse large B-cell lymphoma (DLBCL) remains unclear. Therefore, this study aimed to elucidate frequency and functional characteristics of circulating MAIT cells in DLBCL patients. The findings rev...
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| Language: | English |
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Elsevier
2025-09-01
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| Series: | Translational Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523325001925 |
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| author | Jingru Liu Jiadi Chen Shucheng Chen Yanrong Huang Kaiming Xu Danni Cai Xinai Liao Ruolan You Xiaolin Xu Xiaoting Wang Diyu Hou Shuxia Zhang Fuwen Yang Huifang Huang |
| author_facet | Jingru Liu Jiadi Chen Shucheng Chen Yanrong Huang Kaiming Xu Danni Cai Xinai Liao Ruolan You Xiaolin Xu Xiaoting Wang Diyu Hou Shuxia Zhang Fuwen Yang Huifang Huang |
| author_sort | Jingru Liu |
| collection | DOAJ |
| description | Mucosa-associated invariant T (MAIT) cells are associated with tumor immunity. However, their role in diffuse large B-cell lymphoma (DLBCL) remains unclear. Therefore, this study aimed to elucidate frequency and functional characteristics of circulating MAIT cells in DLBCL patients. The findings revealed a significant reduction in the frequency of circulating MAIT cells in DLBCL patients compared to age-matched healthy controls. Moreover, circulating MAIT cells from DLBCL patients exhibited proapoptotic and senescent phenotypes and demonstrated dysfunction, as evidenced by elevated expression of activation and exhaustion markers, including CD69, CD25, HLA-DR, PD-1, and Tim-3. MAIT cells derived from DLBCL produced lower levels of crucial anti-tumor cytokines, such as interferon-gamma, interleukin-17, tumor necrosis factor-α and granzyme B, suggesting impaired anti-tumor immunity. Additionally, MAIT cells from DLBCL patients showed diminished cytotoxicity against DLBCL cells compared to those from healthy donors. Notably, a lower frequency of circulating MAIT cells in patients with DLBCL was associated with poor prognosis. In summary, this study reveals reduced and impaired circulating MAIT cells in DLBCL patients, suggesting their importance in anti-lymphoma immunity. |
| format | Article |
| id | doaj-art-7af3ce32132c4a53a6b8000bb0e85db0 |
| institution | Kabale University |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-7af3ce32132c4a53a6b8000bb0e85db02025-08-20T03:32:49ZengElsevierTranslational Oncology1936-52332025-09-015910246110.1016/j.tranon.2025.102461Circulating mucosa-associated invariant T cells are decreased and have impaired function in patients with diffuse large B-cell lymphomaJingru Liu0Jiadi Chen1Shucheng Chen2Yanrong Huang3Kaiming Xu4Danni Cai5Xinai Liao6Ruolan You7Xiaolin Xu8Xiaoting Wang9Diyu Hou10Shuxia Zhang11Fuwen Yang12Huifang Huang13Central Laboratory, Fujian Medical University Union Hospital, Fuzhou, ChinaDepartment of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, ChinaCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, China; School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, ChinaCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, China; School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, ChinaCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, ChinaCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, ChinaCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, ChinaCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, ChinaCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, ChinaCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, ChinaCentral Laboratory, Fujian Medical University Union Hospital, Fuzhou, ChinaFujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, The 900th Hospital of the People’s Liberation Army Joint Service Support Force, Fuzhou, China; Corresponding authors.Central Laboratory, Fujian Medical University Union Hospital, Fuzhou, China; Corresponding authors.Mucosa-associated invariant T (MAIT) cells are associated with tumor immunity. However, their role in diffuse large B-cell lymphoma (DLBCL) remains unclear. Therefore, this study aimed to elucidate frequency and functional characteristics of circulating MAIT cells in DLBCL patients. The findings revealed a significant reduction in the frequency of circulating MAIT cells in DLBCL patients compared to age-matched healthy controls. Moreover, circulating MAIT cells from DLBCL patients exhibited proapoptotic and senescent phenotypes and demonstrated dysfunction, as evidenced by elevated expression of activation and exhaustion markers, including CD69, CD25, HLA-DR, PD-1, and Tim-3. MAIT cells derived from DLBCL produced lower levels of crucial anti-tumor cytokines, such as interferon-gamma, interleukin-17, tumor necrosis factor-α and granzyme B, suggesting impaired anti-tumor immunity. Additionally, MAIT cells from DLBCL patients showed diminished cytotoxicity against DLBCL cells compared to those from healthy donors. Notably, a lower frequency of circulating MAIT cells in patients with DLBCL was associated with poor prognosis. In summary, this study reveals reduced and impaired circulating MAIT cells in DLBCL patients, suggesting their importance in anti-lymphoma immunity.http://www.sciencedirect.com/science/article/pii/S1936523325001925Mucosa-associated invariant T cellsDiffuse large B-cell lymphomaDysfunctionPrognosis |
| spellingShingle | Jingru Liu Jiadi Chen Shucheng Chen Yanrong Huang Kaiming Xu Danni Cai Xinai Liao Ruolan You Xiaolin Xu Xiaoting Wang Diyu Hou Shuxia Zhang Fuwen Yang Huifang Huang Circulating mucosa-associated invariant T cells are decreased and have impaired function in patients with diffuse large B-cell lymphoma Translational Oncology Mucosa-associated invariant T cells Diffuse large B-cell lymphoma Dysfunction Prognosis |
| title | Circulating mucosa-associated invariant T cells are decreased and have impaired function in patients with diffuse large B-cell lymphoma |
| title_full | Circulating mucosa-associated invariant T cells are decreased and have impaired function in patients with diffuse large B-cell lymphoma |
| title_fullStr | Circulating mucosa-associated invariant T cells are decreased and have impaired function in patients with diffuse large B-cell lymphoma |
| title_full_unstemmed | Circulating mucosa-associated invariant T cells are decreased and have impaired function in patients with diffuse large B-cell lymphoma |
| title_short | Circulating mucosa-associated invariant T cells are decreased and have impaired function in patients with diffuse large B-cell lymphoma |
| title_sort | circulating mucosa associated invariant t cells are decreased and have impaired function in patients with diffuse large b cell lymphoma |
| topic | Mucosa-associated invariant T cells Diffuse large B-cell lymphoma Dysfunction Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1936523325001925 |
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