Neisseria meningitidis Serogroup Y Sequence Type 1466 and Urogenital Infections
Neisseria meningitidis is a common commensal bacterium of the nasopharynx that can cause invasive meningococcal disease (IMD). In comparison, N. gonorrhoeae is always a pathogen usually limited to mucosal sites. However, increased evidence for overlapping clinical syndromes is emerging. We compared...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-01-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/1/24-0940_article |
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| _version_ | 1850101660806807552 |
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| author | Sebastiaan J. van Hal Thomas Le Frances Jenkins Ratan L. Kundu E. Athena Limnios Lucy A. McNamara Shalabh Sharma Ellen N. Kersh Monica M. Lahra |
| author_facet | Sebastiaan J. van Hal Thomas Le Frances Jenkins Ratan L. Kundu E. Athena Limnios Lucy A. McNamara Shalabh Sharma Ellen N. Kersh Monica M. Lahra |
| author_sort | Sebastiaan J. van Hal |
| collection | DOAJ |
| description |
Neisseria meningitidis is a common commensal bacterium of the nasopharynx that can cause invasive meningococcal disease (IMD). In comparison, N. gonorrhoeae is always a pathogen usually limited to mucosal sites. However, increased evidence for overlapping clinical syndromes is emerging. We compared N. meningitidis samples from a urogenital outbreak in Australia with sequences from the United States and other countries. We conducted phylogenetic analyses to assess relatedness and examine for genomic changes associated with meningococcal adaptation; we collated a total of 255 serogroup Y (MenY), sequence type (ST) 1466 isolate assemblies. Most urogenital isolates originated from Australia; those isolates formed a distinct clade, most closely related genomically to recent US IMD isolates. No specific genomic changes suggested niche adaptation or associated clinical manifestations. The MenY ST1466 N. meningitidis isolates circulating in Australia and the United States are capable of causing both urethritis and invasive meningococcal disease.
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| format | Article |
| id | doaj-art-7aeed7a688414b2f81a086ce263ce9ba |
| institution | DOAJ |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-7aeed7a688414b2f81a086ce263ce9ba2025-08-20T02:39:56ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-01-01311869310.3201/eid3101.240940Neisseria meningitidis Serogroup Y Sequence Type 1466 and Urogenital InfectionsSebastiaan J. van HalThomas LeFrances JenkinsRatan L. KunduE. Athena LimniosLucy A. McNamaraShalabh SharmaEllen N. KershMonica M. Lahra Neisseria meningitidis is a common commensal bacterium of the nasopharynx that can cause invasive meningococcal disease (IMD). In comparison, N. gonorrhoeae is always a pathogen usually limited to mucosal sites. However, increased evidence for overlapping clinical syndromes is emerging. We compared N. meningitidis samples from a urogenital outbreak in Australia with sequences from the United States and other countries. We conducted phylogenetic analyses to assess relatedness and examine for genomic changes associated with meningococcal adaptation; we collated a total of 255 serogroup Y (MenY), sequence type (ST) 1466 isolate assemblies. Most urogenital isolates originated from Australia; those isolates formed a distinct clade, most closely related genomically to recent US IMD isolates. No specific genomic changes suggested niche adaptation or associated clinical manifestations. The MenY ST1466 N. meningitidis isolates circulating in Australia and the United States are capable of causing both urethritis and invasive meningococcal disease. https://wwwnc.cdc.gov/eid/article/31/1/24-0940_articleKeywords: Neisseria meningitidisbacteriameningitis/encephalitisNeisseria gonorrhoeaeurogenital infectionsniche adaptation |
| spellingShingle | Sebastiaan J. van Hal Thomas Le Frances Jenkins Ratan L. Kundu E. Athena Limnios Lucy A. McNamara Shalabh Sharma Ellen N. Kersh Monica M. Lahra Neisseria meningitidis Serogroup Y Sequence Type 1466 and Urogenital Infections Emerging Infectious Diseases Keywords: Neisseria meningitidis bacteria meningitis/encephalitis Neisseria gonorrhoeae urogenital infections niche adaptation |
| title | Neisseria meningitidis Serogroup Y Sequence Type 1466 and Urogenital Infections |
| title_full | Neisseria meningitidis Serogroup Y Sequence Type 1466 and Urogenital Infections |
| title_fullStr | Neisseria meningitidis Serogroup Y Sequence Type 1466 and Urogenital Infections |
| title_full_unstemmed | Neisseria meningitidis Serogroup Y Sequence Type 1466 and Urogenital Infections |
| title_short | Neisseria meningitidis Serogroup Y Sequence Type 1466 and Urogenital Infections |
| title_sort | neisseria meningitidis serogroup y sequence type 1466 and urogenital infections |
| topic | Keywords: Neisseria meningitidis bacteria meningitis/encephalitis Neisseria gonorrhoeae urogenital infections niche adaptation |
| url | https://wwwnc.cdc.gov/eid/article/31/1/24-0940_article |
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