Genetically Engineered Microorganisms and Their Impact on Human Health
The emergence of antibiotic-resistant strains, the decreased effectiveness of conventional therapies, and the side effects have led researchers to seek a safer, more cost-effective, patient-friendly, and effective method that does not develop antibiotic resistance. With progress in synthetic biology...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | International Journal of Clinical Practice |
| Online Access: | http://dx.doi.org/10.1155/2024/6638269 |
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| _version_ | 1849410520222793728 |
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| author | Marzie Mahdizade Ari Leila Dadgar Zahra Elahi Roya Ghanavati Behrouz Taheri |
| author_facet | Marzie Mahdizade Ari Leila Dadgar Zahra Elahi Roya Ghanavati Behrouz Taheri |
| author_sort | Marzie Mahdizade Ari |
| collection | DOAJ |
| description | The emergence of antibiotic-resistant strains, the decreased effectiveness of conventional therapies, and the side effects have led researchers to seek a safer, more cost-effective, patient-friendly, and effective method that does not develop antibiotic resistance. With progress in synthetic biology and genetic engineering, genetically engineered microorganisms effective in treatment, prophylaxis, drug delivery, and diagnosis have been developed. The present study reviews the types of genetically engineered bacteria and phages, their impacts on diseases, cancer, and metabolic and inflammatory disorders, the biosynthesis of these modified strains, the route of administration, and their effects on the environment. We conclude that genetically engineered microorganisms can be considered promising candidates for adjunctive treatment of diseases and cancers. |
| format | Article |
| id | doaj-art-7aec5082946a42289736cc5dfb1ba510 |
| institution | Kabale University |
| issn | 1742-1241 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Clinical Practice |
| spelling | doaj-art-7aec5082946a42289736cc5dfb1ba5102025-08-20T03:35:06ZengWileyInternational Journal of Clinical Practice1742-12412024-01-01202410.1155/2024/6638269Genetically Engineered Microorganisms and Their Impact on Human HealthMarzie Mahdizade Ari0Leila Dadgar1Zahra Elahi2Roya Ghanavati3Behrouz Taheri4Department of MicrobiologyDepartment of MicrobiologyDepartment of MicrobiologyBehbahan Faculty of Medical SciencesDepartment of BiotechnologyThe emergence of antibiotic-resistant strains, the decreased effectiveness of conventional therapies, and the side effects have led researchers to seek a safer, more cost-effective, patient-friendly, and effective method that does not develop antibiotic resistance. With progress in synthetic biology and genetic engineering, genetically engineered microorganisms effective in treatment, prophylaxis, drug delivery, and diagnosis have been developed. The present study reviews the types of genetically engineered bacteria and phages, their impacts on diseases, cancer, and metabolic and inflammatory disorders, the biosynthesis of these modified strains, the route of administration, and their effects on the environment. We conclude that genetically engineered microorganisms can be considered promising candidates for adjunctive treatment of diseases and cancers.http://dx.doi.org/10.1155/2024/6638269 |
| spellingShingle | Marzie Mahdizade Ari Leila Dadgar Zahra Elahi Roya Ghanavati Behrouz Taheri Genetically Engineered Microorganisms and Their Impact on Human Health International Journal of Clinical Practice |
| title | Genetically Engineered Microorganisms and Their Impact on Human Health |
| title_full | Genetically Engineered Microorganisms and Their Impact on Human Health |
| title_fullStr | Genetically Engineered Microorganisms and Their Impact on Human Health |
| title_full_unstemmed | Genetically Engineered Microorganisms and Their Impact on Human Health |
| title_short | Genetically Engineered Microorganisms and Their Impact on Human Health |
| title_sort | genetically engineered microorganisms and their impact on human health |
| url | http://dx.doi.org/10.1155/2024/6638269 |
| work_keys_str_mv | AT marziemahdizadeari geneticallyengineeredmicroorganismsandtheirimpactonhumanhealth AT leiladadgar geneticallyengineeredmicroorganismsandtheirimpactonhumanhealth AT zahraelahi geneticallyengineeredmicroorganismsandtheirimpactonhumanhealth AT royaghanavati geneticallyengineeredmicroorganismsandtheirimpactonhumanhealth AT behrouztaheri geneticallyengineeredmicroorganismsandtheirimpactonhumanhealth |