Prognostic factors of subacute comprehensive encephalitis: a retrospective study
Purpose The etiology of encephalitis is unknown in 40%–50% of cases, so a comprehensive examination of encephalitis would be significant and meaningful. The short-term outcomes in appropriately managed patients are also unknown. Short-term clinical outcomes following onset can provide clinicians wit...
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| Format: | Article |
| Language: | English |
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Korean Encephalitis and Neuroinflammation Society
2025-01-01
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| Series: | Encephalitis |
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| Online Access: | http://encephalitisjournal.org/upload/pdf/encephalitis-2024-00136.pdf |
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| _version_ | 1841550852969463808 |
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| author | Hiroshi Kataoka Hitoki Nanaura Kazuma Sugie |
| author_facet | Hiroshi Kataoka Hitoki Nanaura Kazuma Sugie |
| author_sort | Hiroshi Kataoka |
| collection | DOAJ |
| description | Purpose The etiology of encephalitis is unknown in 40%–50% of cases, so a comprehensive examination of encephalitis would be significant and meaningful. The short-term outcomes in appropriately managed patients are also unknown. Short-term clinical outcomes following onset can provide clinicians with clues regarding the clinical course in the immediate future. We investigated cases of encephalitis, including viral and autoimmune encephalitis, to determine the predictable risk factors that can be assessed to determine a short-term prognosis. Methods We studied 90 patients with encephalitis. Poor and good outcomes were defined as scores of ≥3 and ≤2 on the modified Rankin scale, respectively. Multivariate logistic regression analysis using 19 independent variables was performed. Results Multivariate logistic regression analysis identified cranial magnetic resonance imaging (MRI) lesions (odds ratio [OR], 3.119; 95% confidence interval [CI], 1.166–8.344; p = 0.023) and the need for mechanical ventilation (OR, 4.461; 95% CI, 1.685–11.813; p = 0.003)) as being significantly associated with poor outcomes. In 57 patients with subacute encephalitis presenting with cranial MRI lesions, bilateral lesions on cranial MRI (OR, 5.078; 95% CI, 1.516–17.007; p = 0.008) and the need for mechanical ventilation (OR, 4.461; 95% CI, 1.135–13.584; p = 0.031) were significantly associated with poor outcomes. Conclusion The location of brain lesions, lateral or bilateral, on the initial MRI during the acute phase of encephalitis may be a useful predictor of the outcome during the first 2 months after encephalitis onset, even in cases of encephalitis of unknown etiology. |
| format | Article |
| id | doaj-art-7aeb473176124e2e9d0e91a656f7a302 |
| institution | Kabale University |
| issn | 2765-4559 2734-1461 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Encephalitis and Neuroinflammation Society |
| record_format | Article |
| series | Encephalitis |
| spelling | doaj-art-7aeb473176124e2e9d0e91a656f7a3022025-01-09T23:24:29ZengKorean Encephalitis and Neuroinflammation SocietyEncephalitis2765-45592734-14612025-01-015161410.47936/encephalitis.2024.0013681Prognostic factors of subacute comprehensive encephalitis: a retrospective studyHiroshi Kataoka0Hitoki Nanaura1Kazuma Sugie2Department of Neurology, Nara Medical University, Nara, JapanDepartment of Neurology, Nara Medical University, Nara, JapanDepartment of Neurology, Nara Medical University, Nara, JapanPurpose The etiology of encephalitis is unknown in 40%–50% of cases, so a comprehensive examination of encephalitis would be significant and meaningful. The short-term outcomes in appropriately managed patients are also unknown. Short-term clinical outcomes following onset can provide clinicians with clues regarding the clinical course in the immediate future. We investigated cases of encephalitis, including viral and autoimmune encephalitis, to determine the predictable risk factors that can be assessed to determine a short-term prognosis. Methods We studied 90 patients with encephalitis. Poor and good outcomes were defined as scores of ≥3 and ≤2 on the modified Rankin scale, respectively. Multivariate logistic regression analysis using 19 independent variables was performed. Results Multivariate logistic regression analysis identified cranial magnetic resonance imaging (MRI) lesions (odds ratio [OR], 3.119; 95% confidence interval [CI], 1.166–8.344; p = 0.023) and the need for mechanical ventilation (OR, 4.461; 95% CI, 1.685–11.813; p = 0.003)) as being significantly associated with poor outcomes. In 57 patients with subacute encephalitis presenting with cranial MRI lesions, bilateral lesions on cranial MRI (OR, 5.078; 95% CI, 1.516–17.007; p = 0.008) and the need for mechanical ventilation (OR, 4.461; 95% CI, 1.135–13.584; p = 0.031) were significantly associated with poor outcomes. Conclusion The location of brain lesions, lateral or bilateral, on the initial MRI during the acute phase of encephalitis may be a useful predictor of the outcome during the first 2 months after encephalitis onset, even in cases of encephalitis of unknown etiology.http://encephalitisjournal.org/upload/pdf/encephalitis-2024-00136.pdfencephalitisprognosisoutcomemagnetic resonance imagingmechanical ventilation |
| spellingShingle | Hiroshi Kataoka Hitoki Nanaura Kazuma Sugie Prognostic factors of subacute comprehensive encephalitis: a retrospective study Encephalitis encephalitis prognosis outcome magnetic resonance imaging mechanical ventilation |
| title | Prognostic factors of subacute comprehensive encephalitis: a retrospective study |
| title_full | Prognostic factors of subacute comprehensive encephalitis: a retrospective study |
| title_fullStr | Prognostic factors of subacute comprehensive encephalitis: a retrospective study |
| title_full_unstemmed | Prognostic factors of subacute comprehensive encephalitis: a retrospective study |
| title_short | Prognostic factors of subacute comprehensive encephalitis: a retrospective study |
| title_sort | prognostic factors of subacute comprehensive encephalitis a retrospective study |
| topic | encephalitis prognosis outcome magnetic resonance imaging mechanical ventilation |
| url | http://encephalitisjournal.org/upload/pdf/encephalitis-2024-00136.pdf |
| work_keys_str_mv | AT hiroshikataoka prognosticfactorsofsubacutecomprehensiveencephalitisaretrospectivestudy AT hitokinanaura prognosticfactorsofsubacutecomprehensiveencephalitisaretrospectivestudy AT kazumasugie prognosticfactorsofsubacutecomprehensiveencephalitisaretrospectivestudy |