Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

Type 2 diabetes mellitus (T2DM) is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction which is closely related to apoptosis of β‐cells. Aquaporin 7 (AQP7) is the only aquaglyceroporin protein expressed in pancreatic β‐cells. However, the relationship b...

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Bibliographic Details
Main Authors: Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:FEBS Open Bio
Subjects:
apoptosis
aquaporin 7
autophagy
MAPK
palmitate
Online Access:https://doi.org/10.1002/2211-5463.70011
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