Cancer-associated fibroblasts-derived exosomal piR-35462 promotes the progression of oral squamous cell carcinoma via FTO/Twist1 pathway

Cancer-associated fibroblasts-derived exosomal piR-35462 promotes the progression of oral squamous cell carcinoma via FTO/Twist1 pathway

Abstract Background Cancer-associated fibroblasts (CAFs) represent a crucial component of tumor stroma and play critical roles in cancer progression. However, the role of CAFs derived exosomes in oral squamous cell carcinoma (OSCC) environment is unexplored. PIWI-interacting RNAs (piRNAs) serve as e...

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Main Authors: Yushan Ye, Fan Wu, Bowen Li, Hanyu Ma, Lianxi Mai, Yu Peng, Xiaodi Feng, Xiao Tan, Min Fu, Yongmei Tan, Tianjun Lan, Ruixin Wang, Siqi Ren, Jinsong Li, Shaohai Chang, Shule Xie
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Oral Health
Subjects:
Cancer-associated fibroblasts
Oral squamous cell carcinoma
Exosome
piRNA
Epithelial-mesenchymal transition
Online Access:https://doi.org/10.1186/s12903-025-06082-3
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