Adjunctive diagnostic tool for histopathological classification of congenital mesoblastic nephroma based in molecular genetic findings

Adjunctive diagnostic tool for histopathological classification of congenital mesoblastic nephroma based in molecular genetic findings

Abstract Purpose Congenital mesoblastic nephromas (CMN) are histologically classified into classical, cellular, and mixed subtypes. Most cellular CMNs harbor ETV6-NTRK3 gene fusions, and classic and mixed CMNs harbor EGFR internal tandem duplications (EGFR-ITDs). Classic CMNs are considered benign,...

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Main Authors: Hiroshi Hamada, Kenichi Kohashi, Takeshi Iwasaki, Mikiko Hashisako, Yuko Hino, Masahiro Fukuhara, Amane Kamouchi, Naonori Kawakubo, Tatsuro Tajiri, Yoshinao Oda
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Journal of Cancer Research and Clinical Oncology
Subjects:
Congenital mesoblastic nephroma
Bioinformatics
Gene expression analysis
Surrogate marker
Online Access:https://doi.org/10.1007/s00432-025-06116-x
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