Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India
Objective: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface...
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| Format: | Article |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2013-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2013;volume=34;issue=4;spage=280;epage=282;aulast=Mukhopadhyay |
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| author | Ashis Mukhopadhyay Sudeshna Gangopadhyay Swati Dasgupta Samrat Paul Soma Mukhopadhyay Ujjal Kanti Ray |
| author_facet | Ashis Mukhopadhyay Sudeshna Gangopadhyay Swati Dasgupta Samrat Paul Soma Mukhopadhyay Ujjal Kanti Ray |
| author_sort | Ashis Mukhopadhyay |
| collection | DOAJ |
| description | Objective: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface markers involved with respect to disease surveillance thereby highlighting it as a strong prognostic marker for future diagnosis and treatment. Materials and Methods: A total of 500 consecutively selected ALL patients were diagnosed and treated according to National Cancer Institute protocol (MCP 841) for a period of 24-88 months during this hospital-based study. Results: Of the total, 50.4% had a higher incidence of T-ALL and 47.6% had pro-B, B-cell precursor ALL. Disease free survival and event free survival were remarkably higher in B-ALL adolescent patients as compared to T-ALL, who had significantly lower overall survival ratio. Prevalence of T-ALL was also observed in relapse cases for adolescent patients. Conclusions: We conclude that there is an increased prevalence of T-ALL among adolescents in Eastern India. Immunophenotypic analysis might help in proper evaluation and prediction of treatment outcomes with an increased thrust on studying age-specific incident rates enabling well planned future treatments for improved and better outcome. |
| format | Article |
| id | doaj-art-7ada14a3fe8b478a915989b3735b33eb |
| institution | OA Journals |
| issn | 0971-5851 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-7ada14a3fe8b478a915989b3735b33eb2025-08-20T01:51:11ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512013-01-0134428028210.4103/0971-5851.125245Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern IndiaAshis MukhopadhyaySudeshna GangopadhyaySwati DasguptaSamrat PaulSoma MukhopadhyayUjjal Kanti RayObjective: Research in Eastern India especially among children and adolescents for acute lymphoblastic leukemia (ALL) have not been well documented until recently when it was conducted at a cancer institute of tertiary care with primary objectives of examining and correlating different cell surface markers involved with respect to disease surveillance thereby highlighting it as a strong prognostic marker for future diagnosis and treatment. Materials and Methods: A total of 500 consecutively selected ALL patients were diagnosed and treated according to National Cancer Institute protocol (MCP 841) for a period of 24-88 months during this hospital-based study. Results: Of the total, 50.4% had a higher incidence of T-ALL and 47.6% had pro-B, B-cell precursor ALL. Disease free survival and event free survival were remarkably higher in B-ALL adolescent patients as compared to T-ALL, who had significantly lower overall survival ratio. Prevalence of T-ALL was also observed in relapse cases for adolescent patients. Conclusions: We conclude that there is an increased prevalence of T-ALL among adolescents in Eastern India. Immunophenotypic analysis might help in proper evaluation and prediction of treatment outcomes with an increased thrust on studying age-specific incident rates enabling well planned future treatments for improved and better outcome.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2013;volume=34;issue=4;spage=280;epage=282;aulast=MukhopadhyayAcute lymphoblastic leukemiaB-acute lymphoblastic leukemiaimmunophenotypeprognostic markerT-acute lymphoblastic leukemia |
| spellingShingle | Ashis Mukhopadhyay Sudeshna Gangopadhyay Swati Dasgupta Samrat Paul Soma Mukhopadhyay Ujjal Kanti Ray Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India Indian Journal of Medical and Paediatric Oncology Acute lymphoblastic leukemia B-acute lymphoblastic leukemia immunophenotype prognostic marker T-acute lymphoblastic leukemia |
| title | Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
| title_full | Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
| title_fullStr | Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
| title_full_unstemmed | Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
| title_short | Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India |
| title_sort | surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents an experience from eastern india |
| topic | Acute lymphoblastic leukemia B-acute lymphoblastic leukemia immunophenotype prognostic marker T-acute lymphoblastic leukemia |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2013;volume=34;issue=4;spage=280;epage=282;aulast=Mukhopadhyay |
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