Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria Surgery
Buprenorphine has gained widespread popularity for use in rabbits, while much less is known about methadone. Our aim was to compare sedative, analgesic, and respiratory effects of methadone and buprenorphine as part of balanced anaesthesia. Forty-eight female New Zealand white rabbits undergoing cal...
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2025-06-01
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| author | Daniela Casoni Chiara Parodi Luisana Gisela Garcia Casalta Kay Nettelbeck Claudia Spadavecchia |
| author_facet | Daniela Casoni Chiara Parodi Luisana Gisela Garcia Casalta Kay Nettelbeck Claudia Spadavecchia |
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| description | Buprenorphine has gained widespread popularity for use in rabbits, while much less is known about methadone. Our aim was to compare sedative, analgesic, and respiratory effects of methadone and buprenorphine as part of balanced anaesthesia. Forty-eight female New Zealand white rabbits undergoing calvaria defects were randomly equally assigned to receive either 0.03 mg kg<sup>−1</sup> of buprenorphine (group B) or 0.3 mg kg<sup>−1</sup> of methadone (group M) in combination with 15 mg kg<sup>−1</sup> of ketamine and 0.1 mg kg<sup>−1</sup> of dexmedetomidine SC. Fifteen minutes later, sedation was scored. A laryngeal mask was placed, and inhalational anaesthesia started. Rescue intraoperative analgesia was administered based on autonomic variations. Arterial blood gases were analysed intra- and postoperatively. Postoperative analgesia was administered if the Rabbit Grimace Scale (RbtGS) score was ≥4. The Mann–Whitney test, <i>t</i>-test, and relative risk followed by chi-square test were used to compare the treatment groups. Deeper sedation was observed in rabbits of group M than in those of group B. Rescue analgesia was administered intraoperatively to seven animals in group B and five in group M (<i>p</i> = 0.739) and postoperatively to three in group B and twelve in group M (<i>p</i> = 0.013). Rabbits of both groups showed short-term respiratory acidosis. RbtGS scores indicated better and longer analgesia in group B compared to group M. |
| format | Article |
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| spelling | doaj-art-7ad7fbe15cfb4688bb130bd07dc3ad482025-08-20T03:28:32ZengMDPI AGAnimals2076-26152025-06-011513184310.3390/ani15131843Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria SurgeryDaniela Casoni0Chiara Parodi1Luisana Gisela Garcia Casalta2Kay Nettelbeck3Claudia Spadavecchia4Experimental Surgery Facility, Experimental Animal Center, University of Bern, 3010 Bern, SwitzerlandExperimental Surgery Facility, Experimental Animal Center, University of Bern, 3010 Bern, SwitzerlandExperimental Surgery Facility, Experimental Animal Center, University of Bern, 3010 Bern, SwitzerlandExperimental Surgery Facility, Experimental Animal Center, University of Bern, 3010 Bern, SwitzerlandAnaesthesia Division, Department of Clinical Veterinary Science, Vetsuisse Faculty, University of Bern, 3012 Bern, SwitzerlandBuprenorphine has gained widespread popularity for use in rabbits, while much less is known about methadone. Our aim was to compare sedative, analgesic, and respiratory effects of methadone and buprenorphine as part of balanced anaesthesia. Forty-eight female New Zealand white rabbits undergoing calvaria defects were randomly equally assigned to receive either 0.03 mg kg<sup>−1</sup> of buprenorphine (group B) or 0.3 mg kg<sup>−1</sup> of methadone (group M) in combination with 15 mg kg<sup>−1</sup> of ketamine and 0.1 mg kg<sup>−1</sup> of dexmedetomidine SC. Fifteen minutes later, sedation was scored. A laryngeal mask was placed, and inhalational anaesthesia started. Rescue intraoperative analgesia was administered based on autonomic variations. Arterial blood gases were analysed intra- and postoperatively. Postoperative analgesia was administered if the Rabbit Grimace Scale (RbtGS) score was ≥4. The Mann–Whitney test, <i>t</i>-test, and relative risk followed by chi-square test were used to compare the treatment groups. Deeper sedation was observed in rabbits of group M than in those of group B. Rescue analgesia was administered intraoperatively to seven animals in group B and five in group M (<i>p</i> = 0.739) and postoperatively to three in group B and twelve in group M (<i>p</i> = 0.013). Rabbits of both groups showed short-term respiratory acidosis. RbtGS scores indicated better and longer analgesia in group B compared to group M.https://www.mdpi.com/2076-2615/15/13/1843analgesiarabbitsbone surgeryopioids |
| spellingShingle | Daniela Casoni Chiara Parodi Luisana Gisela Garcia Casalta Kay Nettelbeck Claudia Spadavecchia Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria Surgery Animals analgesia rabbits bone surgery opioids |
| title | Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria Surgery |
| title_full | Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria Surgery |
| title_fullStr | Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria Surgery |
| title_full_unstemmed | Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria Surgery |
| title_short | Buprenorphine Versus Methadone in Female New Zealand White Rabbits Undergoing Balanced Anaesthesia for Calvaria Surgery |
| title_sort | buprenorphine versus methadone in female new zealand white rabbits undergoing balanced anaesthesia for calvaria surgery |
| topic | analgesia rabbits bone surgery opioids |
| url | https://www.mdpi.com/2076-2615/15/13/1843 |
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