The emerging role of proactive therapy in atopic dermatitis and psoriasis
Proactive therapy represents an evolving approach in the long-term management of atopic dermatitis (AD) and psoriasis. Unlike reactive treatment, which targets active symptoms, proactive therapy involves the intermittent, low-dose application of anti-inflammatory agents to previously affected but c...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-04-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/59456 |
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| author | Justyna Pięta Marcel Chudzikowski Patryk Dudek Klaudia Łuczak Agnieszka Pawlik Agata Prokopiuk Joanna Prus Adrianna Tabeau Wiktoria Ulicka Hanna Sitarek |
| author_facet | Justyna Pięta Marcel Chudzikowski Patryk Dudek Klaudia Łuczak Agnieszka Pawlik Agata Prokopiuk Joanna Prus Adrianna Tabeau Wiktoria Ulicka Hanna Sitarek |
| author_sort | Justyna Pięta |
| collection | DOAJ |
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Proactive therapy represents an evolving approach in the long-term management of atopic dermatitis (AD) and psoriasis. Unlike reactive treatment, which targets active symptoms, proactive therapy involves the intermittent, low-dose application of anti-inflammatory agents to previously affected but clinically healed skin to prevent flare-ups. This strategy aims to reduce subclinical inflammation, extend remission periods, and improve patient quality of life. A growing body of evidence supports the efficacy of proactive treatment with topical corticosteroids, calcineurin inhibitors, and vitamin D analogues, demonstrating significant reductions in relapse rates and treatment costs. However, patient adherence remains a key challenge, necessitating structured follow-up and patient education initiatives. This review explores the pathophysiological basis of proactive therapy, its clinical applications, and current evidence supporting its role in AD and psoriasis management. Additionally, we discuss safety concerns, particularly regarding skin atrophy and hypothalamic-pituitary-adrenal axis suppression, and highlight emerging therapeutic options. While proactive therapy has demonstrated a favourable benefit-risk profile, further studies are needed to refine treatment protocols and expand its application to broader patient populations.
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| format | Article |
| id | doaj-art-7ad117bc77a24cacaaf7064ccdb77ffb |
| institution | OA Journals |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-7ad117bc77a24cacaaf7064ccdb77ffb2025-08-20T01:56:13ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-04-018010.12775/JEHS.2025.80.59456The emerging role of proactive therapy in atopic dermatitis and psoriasisJustyna Pięta0https://orcid.org/0009-0007-2835-5064Marcel Chudzikowski1https://orcid.org/0009-0003-2268-6154Patryk Dudek2https://orcid.org/0009-0004-9103-7905Klaudia Łuczak3https://orcid.org/0009-0008-8209-0121Agnieszka Pawlik4https://orcid.org/0009-0008-9043-0405Agata Prokopiuk5https://orcid.org/0009-0005-3668-6512Joanna Prus6https://orcid.org/0009-0002-6274-7436Adrianna Tabeau7https://orcid.org/0009-0001-2881-8491Wiktoria Ulickahttps://orcid.org/0009-0003-5442-3439Hanna Sitarek8https://orcid.org/0009-0002-4507-3038Bielański Hospital in WarsawWarsaw Southern Hospital, Rotmistrza Witolda Pileckiego 99, 02-781 WarszawaWarszawski Szpital PołudniowyCentral Clinical Hospital Banacha St. 1A, 02-097 WarsawBielanski Hospital 80 Cegłowska Street, 01-809 WarsawRegional Specialist Hospital in Biała Podlaska Ul. Terebelska 57-65, 21-500 Biała PodlaskaPraski Hospital of Lord's Transfiguration, Aleja “Solidarności'' 67, 03-401, Warsaw, PolandCentral Clinical HospitalSt John Paul II Independent Public Specialist Western Hospital Daleka 11, 05-825 Grodzisk Mazowiecki, Poland Proactive therapy represents an evolving approach in the long-term management of atopic dermatitis (AD) and psoriasis. Unlike reactive treatment, which targets active symptoms, proactive therapy involves the intermittent, low-dose application of anti-inflammatory agents to previously affected but clinically healed skin to prevent flare-ups. This strategy aims to reduce subclinical inflammation, extend remission periods, and improve patient quality of life. A growing body of evidence supports the efficacy of proactive treatment with topical corticosteroids, calcineurin inhibitors, and vitamin D analogues, demonstrating significant reductions in relapse rates and treatment costs. However, patient adherence remains a key challenge, necessitating structured follow-up and patient education initiatives. This review explores the pathophysiological basis of proactive therapy, its clinical applications, and current evidence supporting its role in AD and psoriasis management. Additionally, we discuss safety concerns, particularly regarding skin atrophy and hypothalamic-pituitary-adrenal axis suppression, and highlight emerging therapeutic options. While proactive therapy has demonstrated a favourable benefit-risk profile, further studies are needed to refine treatment protocols and expand its application to broader patient populations. https://apcz.umk.pl/JEHS/article/view/59456proactive therapymaintenance therapytopical treatmentatopic dermatitispsoriasis |
| spellingShingle | Justyna Pięta Marcel Chudzikowski Patryk Dudek Klaudia Łuczak Agnieszka Pawlik Agata Prokopiuk Joanna Prus Adrianna Tabeau Wiktoria Ulicka Hanna Sitarek The emerging role of proactive therapy in atopic dermatitis and psoriasis Journal of Education, Health and Sport proactive therapy maintenance therapy topical treatment atopic dermatitis psoriasis |
| title | The emerging role of proactive therapy in atopic dermatitis and psoriasis |
| title_full | The emerging role of proactive therapy in atopic dermatitis and psoriasis |
| title_fullStr | The emerging role of proactive therapy in atopic dermatitis and psoriasis |
| title_full_unstemmed | The emerging role of proactive therapy in atopic dermatitis and psoriasis |
| title_short | The emerging role of proactive therapy in atopic dermatitis and psoriasis |
| title_sort | emerging role of proactive therapy in atopic dermatitis and psoriasis |
| topic | proactive therapy maintenance therapy topical treatment atopic dermatitis psoriasis |
| url | https://apcz.umk.pl/JEHS/article/view/59456 |
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