Gut expression of CD71 and co-localisation with Dec-1 associated with high levels of serum SIgA and disease activity in SpA

Gut expression of CD71 and co-localisation with Dec-1 associated with high levels of serum SIgA and disease activity in SpA

Abstract Spondyloarthritis (SpA) correlates with elevated serum secretory-IgA (sSIgA). Retrotranscytosis, mediated by CD71 and Dectin-1, is linked to high sSIgA levels. This research investigated retrotranscytosis in the gut of SpA patients and its relationship with sSIgA, ileocolonoscopic findings,...

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Main Authors: Juliette De Ávila, Alejandro Ramos-Casallas, Myriam Lucia Velandia-Romero, Sandra Janneth Perdomo-Lara, Diana Acero-Molina, Cristian Florez-Sarmiento, Viviana Parra-Izquierdo, Jaime E. Castellanos, Lorena Chila-Moreno, Wilson Bautista-Molano, Adriana Beltran-Ostos, Diego Alejandro Jaimes, Juan Manuel Bello-Gualtero, Cesar Pacheco-Tena, Philippe Chalem, Consuelo Romero-Sánchez
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Spondyloarthritis
Subclinical gut involvement
Serum secretory IgA
Retrotranscytosis
Transferrin receptor (CD71)
Dectin-1
Online Access:https://doi.org/10.1038/s41598-025-03532-4
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