Acute high-fat high-sugar diet rapidly increases blood-brain barrier permeability in mice

Acute high-fat high-sugar diet rapidly increases blood-brain barrier permeability in mice

The blood-brain barrier (BBB) maintains brain homeostasis by protecting the brain from pathological stimuli and controlling the entry of physiological substances from the periphery. Consequently, alterations in BBB permeability may pose a threat to brain health. Long-term consumption of a high-fat h...

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Bibliographic Details
Main Authors: Este Leidmaa, Andreas Zimmer, Valentin Stein, Anne-Kathrin Gellner
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:The Journal of Nutrition, Health and Aging
Subjects:
Western diet
Palatable food
Vascular leakage
BBB integrity
Drug delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S1279770725000983
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