Acute high-fat high-sugar diet rapidly increases blood-brain barrier permeability in mice
The blood-brain barrier (BBB) maintains brain homeostasis by protecting the brain from pathological stimuli and controlling the entry of physiological substances from the periphery. Consequently, alterations in BBB permeability may pose a threat to brain health. Long-term consumption of a high-fat h...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
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| Series: | The Journal of Nutrition, Health and Aging |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1279770725000983 |
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| Summary: | The blood-brain barrier (BBB) maintains brain homeostasis by protecting the brain from pathological stimuli and controlling the entry of physiological substances from the periphery. Consequently, alterations in BBB permeability may pose a threat to brain health. Long-term consumption of a high-fat high-sugar/Western diet (HFD) is known to induce BBB dysfunction. However, nothing is known about the immediate effects of acute HFD consumption on the BBB. Using spectrophotometry and in vivo 2-photon microscopy in mice, we demonstrate region-specific BBB leakage already after 1 h of HFD for low- and high-molecular-weight tracers. Acute HFD also significantly increased BBB permeability to the anticancer drug doxorubicin. These previously unknown effects of acute HFD in mice may have far-reaching implications for the clinical use of drugs depending on the dietary habits of the patient, and might inform future studies on drug transport to the brain. |
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| ISSN: | 1760-4788 |