Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort
Introduction: Cancer treatments have a detrimental impact on the quality of life (QoL) of young women with breast cancer (YWBC). Research exploring QoL trajectories has been mostly centered on postmenopausal women. Here we report longitudinal changes across all QoL domains and associated factors in...
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| Format: | Article |
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Elsevier
2025-02-01
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| Series: | Breast |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0960977624001978 |
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| author | Bryan F. Vaca-Cartagena Ana S. Ferrigno Guajardo Hatem A. Azim Jr Federico Rotolo Antonio Olivas-Martinez Alejandra Platas Alan Fonseca Fernanda Mesa-Chavez Marlid Cruz-Ramos Ana Rodriguez Alejandro Mohar Cynthia Villarreal-Garza |
| author_facet | Bryan F. Vaca-Cartagena Ana S. Ferrigno Guajardo Hatem A. Azim Jr Federico Rotolo Antonio Olivas-Martinez Alejandra Platas Alan Fonseca Fernanda Mesa-Chavez Marlid Cruz-Ramos Ana Rodriguez Alejandro Mohar Cynthia Villarreal-Garza |
| author_sort | Bryan F. Vaca-Cartagena |
| collection | DOAJ |
| description | Introduction: Cancer treatments have a detrimental impact on the quality of life (QoL) of young women with breast cancer (YWBC). Research exploring QoL trajectories has been mostly centered on postmenopausal women. Here we report longitudinal changes across all QoL domains and associated factors in YWBC. Methods: In this prospective longitudinal cohort study, women aged ≤40 with stage I-III BC completed the European Organization for the Research and Treatment of Cancer Core QoL questionnaire at diagnosis and during 4 follow-up visits over 5 years, alongside demographic and clinical data collection. Group-based multivariate trajectory modeling was used to identify patient groups based on their functional and symptom scores, finding 3 groups (best, good, and poor). Factors associated with each trajectory pattern were identified with multinomial logistic models. Results: A total of 477 women (median age: 36; IQR: 32–38) were clustered into the best (n = 259, 54 %), good (n = 79, 17 %), or poor trajectory groups (n = 139, 29 %). Throughout the disease, patients with a poor QoL experienced clinically significant impairment in emotional functioning, nausea and vomiting, and pain. They also had significant cognitive impairment, dyspnea, and diarrhea. Patients with a good QoL had clinically meaningful diarrhea for the first 7 months, while those with the best QoL had clinically important nausea and vomiting during the first 2 months since diagnosis. Noteworthy, all groups experienced significant financial difficulties throughout their follow-up. Regular alcohol consumption at diagnosis (aOR [adjusted odds ratio] 1.64; 95 % CI [confidence interval] 1.02–2.65) and HER2-positive BC (aOR 2.53; 95 % CI 1.35–4.73) were independent factors associated with classification to the poor and good groups, respectively. Conclusion: This study underscores the variability in QoL among YWBC and the importance of ongoing monitoring. Strategies to improve access to economic resources, manage treatment-related adverse effects, and support patients in discontinuing modifiable risk factors are needed. |
| format | Article |
| id | doaj-art-7acb3cae284d40c5a5df7c22fd9d614c |
| institution | Kabale University |
| issn | 1532-3080 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Breast |
| spelling | doaj-art-7acb3cae284d40c5a5df7c22fd9d614c2025-02-12T05:30:37ZengElsevierBreast1532-30802025-02-0179103866Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohortBryan F. Vaca-Cartagena0Ana S. Ferrigno Guajardo1Hatem A. Azim Jr2Federico Rotolo3Antonio Olivas-Martinez4Alejandra Platas5Alan Fonseca6Fernanda Mesa-Chavez7Marlid Cruz-Ramos8Ana Rodriguez9Alejandro Mohar10Cynthia Villarreal-Garza11Breast Cancer Center, Hospital Zambrano Hellion TecSalud, Tecnologico de Monterrey, San Pedro Garza García, MexicoDepartment of Medicine, Yale University School of Medicine, New Haven, CT, USABreast Cancer Center, Hospital Zambrano Hellion TecSalud, Tecnologico de Monterrey, San Pedro Garza García, MexicoBiomarkers Statistics, Sanofi, Montpellier, FranceDepartment of Biostatistics, University of Washington, Seattle, WA, USADepartamento de Investigacion y de Tumores Mamarios, Instituto Nacional de Cancerologia, Ciudad de Mexico, Mexico; MILC, Médicos e Investigadores en la Lucha contra el Cáncer de Mama, Ciudad De México, MexicoDepartamento de Investigacion y de Tumores Mamarios, Instituto Nacional de Cancerologia, Ciudad de Mexico, MexicoBreast Cancer Center, Hospital Zambrano Hellion TecSalud, Tecnologico de Monterrey, San Pedro Garza García, MexicoInvestigadora por México del Consejo Nacional de Humanidades, Ciencias y Tecnologías (CONAHCYT), Instituto Nacional de Cancerologia, Ciudad de Mexico, MexicoMILC, Médicos e Investigadores en la Lucha contra el Cáncer de Mama, Ciudad De México, MexicoUnidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología e Instituto de Investigaciones Biomédicas, UNAM, Ciudad de Mexico, MexicoBreast Cancer Center, Hospital Zambrano Hellion TecSalud, Tecnologico de Monterrey, San Pedro Garza García, Mexico; MILC, Médicos e Investigadores en la Lucha contra el Cáncer de Mama, Ciudad De México, Mexico; Corresponding author. Batallón de San Patricio 112, Real San Agustín, 66260, San Pedro Garza García, Mexico.Introduction: Cancer treatments have a detrimental impact on the quality of life (QoL) of young women with breast cancer (YWBC). Research exploring QoL trajectories has been mostly centered on postmenopausal women. Here we report longitudinal changes across all QoL domains and associated factors in YWBC. Methods: In this prospective longitudinal cohort study, women aged ≤40 with stage I-III BC completed the European Organization for the Research and Treatment of Cancer Core QoL questionnaire at diagnosis and during 4 follow-up visits over 5 years, alongside demographic and clinical data collection. Group-based multivariate trajectory modeling was used to identify patient groups based on their functional and symptom scores, finding 3 groups (best, good, and poor). Factors associated with each trajectory pattern were identified with multinomial logistic models. Results: A total of 477 women (median age: 36; IQR: 32–38) were clustered into the best (n = 259, 54 %), good (n = 79, 17 %), or poor trajectory groups (n = 139, 29 %). Throughout the disease, patients with a poor QoL experienced clinically significant impairment in emotional functioning, nausea and vomiting, and pain. They also had significant cognitive impairment, dyspnea, and diarrhea. Patients with a good QoL had clinically meaningful diarrhea for the first 7 months, while those with the best QoL had clinically important nausea and vomiting during the first 2 months since diagnosis. Noteworthy, all groups experienced significant financial difficulties throughout their follow-up. Regular alcohol consumption at diagnosis (aOR [adjusted odds ratio] 1.64; 95 % CI [confidence interval] 1.02–2.65) and HER2-positive BC (aOR 2.53; 95 % CI 1.35–4.73) were independent factors associated with classification to the poor and good groups, respectively. Conclusion: This study underscores the variability in QoL among YWBC and the importance of ongoing monitoring. Strategies to improve access to economic resources, manage treatment-related adverse effects, and support patients in discontinuing modifiable risk factors are needed.http://www.sciencedirect.com/science/article/pii/S0960977624001978Breast NeoplasmsQuality of lifeFinancial stressEORTC QLQ-C30Young women with breast caner |
| spellingShingle | Bryan F. Vaca-Cartagena Ana S. Ferrigno Guajardo Hatem A. Azim Jr Federico Rotolo Antonio Olivas-Martinez Alejandra Platas Alan Fonseca Fernanda Mesa-Chavez Marlid Cruz-Ramos Ana Rodriguez Alejandro Mohar Cynthia Villarreal-Garza Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort Breast Breast Neoplasms Quality of life Financial stress EORTC QLQ-C30 Young women with breast caner |
| title | Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort |
| title_full | Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort |
| title_fullStr | Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort |
| title_full_unstemmed | Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort |
| title_short | Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort |
| title_sort | describing quality of life trajectories in young hispanic women with breast cancer 5 year results from a large prospective cohort |
| topic | Breast Neoplasms Quality of life Financial stress EORTC QLQ-C30 Young women with breast caner |
| url | http://www.sciencedirect.com/science/article/pii/S0960977624001978 |
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