In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications
Silver nanoparticles have attracted great interests widely in medicine due to its great characteristics of antibacterial activity. In this research, the antibacterial activity and biocompatibility of a topical gel synthesized from polyvinyl alcohol, chitosan, and silver nanoparticles were studied. H...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2019/7382717 |
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| _version_ | 1832545718694313984 |
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| author | Tan Dat Nguyen Thanh Truc Nguyen Khanh Loan Ly Anh Hien Tran Thi Thanh Ngoc Nguyen Minh Thuy Vo Hieu Minh Ho Ngoc Thao Nhi Dang Van Toi Vo Dai Hai Nguyen Thi Thu Hoai Nguyen Thi Hiep Nguyen |
| author_facet | Tan Dat Nguyen Thanh Truc Nguyen Khanh Loan Ly Anh Hien Tran Thi Thanh Ngoc Nguyen Minh Thuy Vo Hieu Minh Ho Ngoc Thao Nhi Dang Van Toi Vo Dai Hai Nguyen Thi Thu Hoai Nguyen Thi Hiep Nguyen |
| author_sort | Tan Dat Nguyen |
| collection | DOAJ |
| description | Silver nanoparticles have attracted great interests widely in medicine due to its great characteristics of antibacterial activity. In this research, the antibacterial activity and biocompatibility of a topical gel synthesized from polyvinyl alcohol, chitosan, and silver nanoparticles were studied. Hydrogels with different concentrations of silver nanoparticles (15 ppm, 30 ppm, and 60 ppm) were evaluated to compare their antibacterial activity, nanoparticles’ sizes, and in vivo behaviors. The resulted silver nanoparticles in the hydrogel were characterized by TEM showing the nanoparticles’ sizes less than 22 nm. The in vitro results prove that the antibacterial effects of all of the samples are satisfied. However, the in vivo results demonstrate the significant difference among different hydrogels in wound healing, where hydrogel with 30 ppm shows the best healing rate. |
| format | Article |
| id | doaj-art-7ac8e957e44d44e9bfd3ce803f109785 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-7ac8e957e44d44e9bfd3ce803f1097852025-02-03T07:25:01ZengWileyInternational Journal of Polymer Science1687-94221687-94302019-01-01201910.1155/2019/73827177382717In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing ApplicationsTan Dat Nguyen0Thanh Truc Nguyen1Khanh Loan Ly2Anh Hien Tran3Thi Thanh Ngoc Nguyen4Minh Thuy Vo5Hieu Minh Ho6Ngoc Thao Nhi Dang7Van Toi Vo8Dai Hai Nguyen9Thi Thu Hoai Nguyen10Thi Hiep Nguyen11Tissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 700000, VietnamGraduate School of Science and Technology Vietnam, Vietnam Academy of Science and Technology, HCMC 700000, VietnamSchool of Biotechnology, International University, Vietnam National University-Ho Chi Minh City (VNU-HCM), HCMC 700000, VietnamTissue Engineering and Regenerative Medicine Group, Department of Biomedical Engineering, International University, Vietnam National University-HCMC (VNU-HCMC), HCMC 700000, VietnamSilver nanoparticles have attracted great interests widely in medicine due to its great characteristics of antibacterial activity. In this research, the antibacterial activity and biocompatibility of a topical gel synthesized from polyvinyl alcohol, chitosan, and silver nanoparticles were studied. Hydrogels with different concentrations of silver nanoparticles (15 ppm, 30 ppm, and 60 ppm) were evaluated to compare their antibacterial activity, nanoparticles’ sizes, and in vivo behaviors. The resulted silver nanoparticles in the hydrogel were characterized by TEM showing the nanoparticles’ sizes less than 22 nm. The in vitro results prove that the antibacterial effects of all of the samples are satisfied. However, the in vivo results demonstrate the significant difference among different hydrogels in wound healing, where hydrogel with 30 ppm shows the best healing rate.http://dx.doi.org/10.1155/2019/7382717 |
| spellingShingle | Tan Dat Nguyen Thanh Truc Nguyen Khanh Loan Ly Anh Hien Tran Thi Thanh Ngoc Nguyen Minh Thuy Vo Hieu Minh Ho Ngoc Thao Nhi Dang Van Toi Vo Dai Hai Nguyen Thi Thu Hoai Nguyen Thi Hiep Nguyen In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications International Journal of Polymer Science |
| title | In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications |
| title_full | In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications |
| title_fullStr | In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications |
| title_full_unstemmed | In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications |
| title_short | In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications |
| title_sort | in vivo study of the antibacterial chitosan polyvinyl alcohol loaded with silver nanoparticle hydrogel for wound healing applications |
| url | http://dx.doi.org/10.1155/2019/7382717 |
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