The neurexin gene family regulates olfactory glomerular formation
Summary: Precise connectivity between specific neurons is essential for the formation of the complex neural circuitry necessary for executing intricate motor behaviors and higher cognitive functions. While trans interactions between synaptic surface proteins have emerged as crucial elements in orche...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725008964 |
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| author | Sung Jin Park Namgyu Lee I-Hao Wang Hao-Ching Jiang Thuyvan Luu Takeshi Uemura Kensuke Futai Dohoon Kim Evan Macosko Paul Greer |
| author_facet | Sung Jin Park Namgyu Lee I-Hao Wang Hao-Ching Jiang Thuyvan Luu Takeshi Uemura Kensuke Futai Dohoon Kim Evan Macosko Paul Greer |
| author_sort | Sung Jin Park |
| collection | DOAJ |
| description | Summary: Precise connectivity between specific neurons is essential for the formation of the complex neural circuitry necessary for executing intricate motor behaviors and higher cognitive functions. While trans interactions between synaptic surface proteins have emerged as crucial elements in orchestrating the assembly of neural circuits, the proteins involved in neuronal wiring remain largely unknown. Here, we uncover that the neurexin family of genes enables olfactory sensory neuron (OSN) axons to form appropriate connections with their mitral/tufted (M/T) cell synaptic partners within the olfactory system. Neurexins, which are differentially expressed within distinct populations of OSNs, synergistically cooperate to regulate axonal sorting to designated glomeruli. This process is facilitated through the interactions of neurexins with their postsynaptic partners, which have distinct expression patterns in M/T cells. Our findings suggest a mechanism underpinning the precise assembly of olfactory neural circuits, driven by the trans interaction between neurexins and their ligands. |
| format | Article |
| id | doaj-art-7ac6e86e2f9846c3b590bf16a3d43b4a |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-7ac6e86e2f9846c3b590bf16a3d43b4a2025-08-20T04:00:32ZengElsevierCell Reports2211-12472025-08-0144811612510.1016/j.celrep.2025.116125The neurexin gene family regulates olfactory glomerular formationSung Jin Park0Namgyu Lee1I-Hao Wang2Hao-Ching Jiang3Thuyvan Luu4Takeshi Uemura5Kensuke Futai6Dohoon Kim7Evan Macosko8Paul Greer9Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA; Department of Physiology, Sungkyunkwan University School of Medicine, Suwon, South Korea; Department of Biomedical Science & Engineering, Dankook University, Cheonan, South Korea; Corresponding authorDepartment of Biomedical Science & Engineering, Dankook University, Cheonan, South KoreaProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USAProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USAProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USADivision of Gene Research, Research Center for Advanced Science, Shinshu University, Nagano, Japan; Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Nagano, JapanDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USADepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USABroad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USAProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA; Corresponding authorSummary: Precise connectivity between specific neurons is essential for the formation of the complex neural circuitry necessary for executing intricate motor behaviors and higher cognitive functions. While trans interactions between synaptic surface proteins have emerged as crucial elements in orchestrating the assembly of neural circuits, the proteins involved in neuronal wiring remain largely unknown. Here, we uncover that the neurexin family of genes enables olfactory sensory neuron (OSN) axons to form appropriate connections with their mitral/tufted (M/T) cell synaptic partners within the olfactory system. Neurexins, which are differentially expressed within distinct populations of OSNs, synergistically cooperate to regulate axonal sorting to designated glomeruli. This process is facilitated through the interactions of neurexins with their postsynaptic partners, which have distinct expression patterns in M/T cells. Our findings suggest a mechanism underpinning the precise assembly of olfactory neural circuits, driven by the trans interaction between neurexins and their ligands.http://www.sciencedirect.com/science/article/pii/S2211124725008964CP: Neuroscience |
| spellingShingle | Sung Jin Park Namgyu Lee I-Hao Wang Hao-Ching Jiang Thuyvan Luu Takeshi Uemura Kensuke Futai Dohoon Kim Evan Macosko Paul Greer The neurexin gene family regulates olfactory glomerular formation Cell Reports CP: Neuroscience |
| title | The neurexin gene family regulates olfactory glomerular formation |
| title_full | The neurexin gene family regulates olfactory glomerular formation |
| title_fullStr | The neurexin gene family regulates olfactory glomerular formation |
| title_full_unstemmed | The neurexin gene family regulates olfactory glomerular formation |
| title_short | The neurexin gene family regulates olfactory glomerular formation |
| title_sort | neurexin gene family regulates olfactory glomerular formation |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725008964 |
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