Glioma stem cells: drivers of tumor progression and recurrence
Abstract Glioma, a common malignancy of the central nervous system, attracts significant clinical attention due to its poor prognosis. Glioma stem cells (GSCs), characterized by stem-like properties and substantial heterogeneity, play a crucial role in tumor initiation, progression, and potential re...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-025-04352-z |
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| _version_ | 1849724861111336960 |
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| author | Jiaoyan He Xiuwei Yan Shaoshan Hu |
| author_facet | Jiaoyan He Xiuwei Yan Shaoshan Hu |
| author_sort | Jiaoyan He |
| collection | DOAJ |
| description | Abstract Glioma, a common malignancy of the central nervous system, attracts significant clinical attention due to its poor prognosis. Glioma stem cells (GSCs), characterized by stem-like properties and substantial heterogeneity, play a crucial role in tumor initiation, progression, and potential recurrence. Moreover, through complex interaction mechanisms, they contribute to the challenges associated with treatment. This review seeks to explore the distinctive characteristics and underlying mechanisms of GSCs, aiming to provide novel theoretical insights and practical strategies for precision therapy in glioma. |
| format | Article |
| id | doaj-art-7ac5cca6c8bd4df4be12ee5862d532a6 |
| institution | DOAJ |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-7ac5cca6c8bd4df4be12ee5862d532a62025-08-20T03:10:38ZengBMCStem Cell Research & Therapy1757-65122025-06-0116111410.1186/s13287-025-04352-zGlioma stem cells: drivers of tumor progression and recurrenceJiaoyan He0Xiuwei Yan1Shaoshan Hu2Cancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeCancer Center, Department of Neurosurgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical CollegeAbstract Glioma, a common malignancy of the central nervous system, attracts significant clinical attention due to its poor prognosis. Glioma stem cells (GSCs), characterized by stem-like properties and substantial heterogeneity, play a crucial role in tumor initiation, progression, and potential recurrence. Moreover, through complex interaction mechanisms, they contribute to the challenges associated with treatment. This review seeks to explore the distinctive characteristics and underlying mechanisms of GSCs, aiming to provide novel theoretical insights and practical strategies for precision therapy in glioma.https://doi.org/10.1186/s13287-025-04352-zGlioma stem cellsGliomaMechanismImmunityMetabolism |
| spellingShingle | Jiaoyan He Xiuwei Yan Shaoshan Hu Glioma stem cells: drivers of tumor progression and recurrence Stem Cell Research & Therapy Glioma stem cells Glioma Mechanism Immunity Metabolism |
| title | Glioma stem cells: drivers of tumor progression and recurrence |
| title_full | Glioma stem cells: drivers of tumor progression and recurrence |
| title_fullStr | Glioma stem cells: drivers of tumor progression and recurrence |
| title_full_unstemmed | Glioma stem cells: drivers of tumor progression and recurrence |
| title_short | Glioma stem cells: drivers of tumor progression and recurrence |
| title_sort | glioma stem cells drivers of tumor progression and recurrence |
| topic | Glioma stem cells Glioma Mechanism Immunity Metabolism |
| url | https://doi.org/10.1186/s13287-025-04352-z |
| work_keys_str_mv | AT jiaoyanhe gliomastemcellsdriversoftumorprogressionandrecurrence AT xiuweiyan gliomastemcellsdriversoftumorprogressionandrecurrence AT shaoshanhu gliomastemcellsdriversoftumorprogressionandrecurrence |