Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017
BackgroundShanghai has become a modern and international metropolis. A more comprehensive understanding of cancer incidence and mortality rates and socioenvironmental factors is explored to develop effective cancer control policies in Shanghai.MethodsCancer registration data are currently collected...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1615492/full |
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| author | Jiejie Qin Jiejie Qin Jiejie Qin Jiejie Qin Mengyin Wu Shulin Zhao Shulin Zhao Shulin Zhao Kai Gu Renzhi Cai Ziwei Tang Defeng Zhu Jingyan Tian Jingyan Tian Wei Yao Baiyong Shen Baiyong Shen Baiyong Shen Yan Shi |
| author_facet | Jiejie Qin Jiejie Qin Jiejie Qin Jiejie Qin Mengyin Wu Shulin Zhao Shulin Zhao Shulin Zhao Kai Gu Renzhi Cai Ziwei Tang Defeng Zhu Jingyan Tian Jingyan Tian Wei Yao Baiyong Shen Baiyong Shen Baiyong Shen Yan Shi |
| author_sort | Jiejie Qin |
| collection | DOAJ |
| description | BackgroundShanghai has become a modern and international metropolis. A more comprehensive understanding of cancer incidence and mortality rates and socioenvironmental factors is explored to develop effective cancer control policies in Shanghai.MethodsCancer registration data are currently collected in Shanghai from 1973 to 2017, and socioenvironmental factors were obtained from the Shanghai statistical yearbook. Multivariate ridge regression analysis explored the contributions of socioenvironmental factors to cancer incidence and mortality, and the estimated annual percentage change (EAPC) was calculated for each cancer type by gender and district.ResultsMultivariate ridge regression analysis indicated that the number of divorces, total waste gas from industry, areas of buildings completed, and number of computers probably drove the increase in cancer incidence, and health expenditure and medical insurance cost probably contributed to the decrease in cancer mortality in Shanghai. Age-standardized cancer incidences of the lung in female patients, prostate, thyroid, and cervix increased most, and the incidence and mortality of esophagus, liver, and stomach cancers decreased most in Shanghai from 2002 to 2017. The most common cancer sites diagnosed were lung, colorectal, female breast, and male prostate in Shanghai in 2017, similar to the pattern in high-income countries. Stricter air control strategies, lower divorce rates, healthier lifestyles, and more effective HPV vaccination campaigns may be useful actionable measures of cancer prevention.ConclusionsThe longitudinal cancer data from the real world, which span decades, reported here and Shanghai’s experience in cancer prevention and control can be a reference for government guidelines in preventing population-level cancer incidence during city development. |
| format | Article |
| id | doaj-art-7ac425ff63c54112a64201df22ff1a2b |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-7ac425ff63c54112a64201df22ff1a2b2025-08-20T02:47:34ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.16154921615492Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017Jiejie Qin0Jiejie Qin1Jiejie Qin2Jiejie Qin3Mengyin Wu4Shulin Zhao5Shulin Zhao6Shulin Zhao7Kai Gu8Renzhi Cai9Ziwei Tang10Defeng Zhu11Jingyan Tian12Jingyan Tian13Wei Yao14Baiyong Shen15Baiyong Shen16Baiyong Shen17Yan Shi18Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Pancreatic Neoplasms Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaResearch Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaClinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, ChinaDepartment of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Pancreatic Neoplasms Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaResearch Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, ChinaDepartment of Vital Statistics, Division of Health Information, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, ChinaShanghai Institute of Microsystem and information Technology, Chinese Academy of Sciences, Shanghai, ChinaShanghai Institute of Microsystem and information Technology, Chinese Academy of Sciences, Shanghai, ChinaClinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Microsystem and information Technology, Chinese Academy of Sciences, Shanghai, ChinaDepartment of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Pancreatic Neoplasms Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaResearch Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDivision of Noncommunicable Diseases and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, ChinaBackgroundShanghai has become a modern and international metropolis. A more comprehensive understanding of cancer incidence and mortality rates and socioenvironmental factors is explored to develop effective cancer control policies in Shanghai.MethodsCancer registration data are currently collected in Shanghai from 1973 to 2017, and socioenvironmental factors were obtained from the Shanghai statistical yearbook. Multivariate ridge regression analysis explored the contributions of socioenvironmental factors to cancer incidence and mortality, and the estimated annual percentage change (EAPC) was calculated for each cancer type by gender and district.ResultsMultivariate ridge regression analysis indicated that the number of divorces, total waste gas from industry, areas of buildings completed, and number of computers probably drove the increase in cancer incidence, and health expenditure and medical insurance cost probably contributed to the decrease in cancer mortality in Shanghai. Age-standardized cancer incidences of the lung in female patients, prostate, thyroid, and cervix increased most, and the incidence and mortality of esophagus, liver, and stomach cancers decreased most in Shanghai from 2002 to 2017. The most common cancer sites diagnosed were lung, colorectal, female breast, and male prostate in Shanghai in 2017, similar to the pattern in high-income countries. Stricter air control strategies, lower divorce rates, healthier lifestyles, and more effective HPV vaccination campaigns may be useful actionable measures of cancer prevention.ConclusionsThe longitudinal cancer data from the real world, which span decades, reported here and Shanghai’s experience in cancer prevention and control can be a reference for government guidelines in preventing population-level cancer incidence during city development.https://www.frontiersin.org/articles/10.3389/fonc.2025.1615492/fullcancerincidencemortalitytrendsocioenvironmentmetropolitanization |
| spellingShingle | Jiejie Qin Jiejie Qin Jiejie Qin Jiejie Qin Mengyin Wu Shulin Zhao Shulin Zhao Shulin Zhao Kai Gu Renzhi Cai Ziwei Tang Defeng Zhu Jingyan Tian Jingyan Tian Wei Yao Baiyong Shen Baiyong Shen Baiyong Shen Yan Shi Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017 Frontiers in Oncology cancer incidence mortality trend socioenvironment metropolitanization |
| title | Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017 |
| title_full | Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017 |
| title_fullStr | Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017 |
| title_full_unstemmed | Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017 |
| title_short | Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017 |
| title_sort | trends in cancer incidence and mortality in the process of metropolitanization of shanghai 1973 2017 |
| topic | cancer incidence mortality trend socioenvironment metropolitanization |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1615492/full |
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