Minibeam Radiation Therapy for Recurrent Mucosal Melanoma: An Eye-Opening Response
We report a case of novel radiation treatment referred to as minibeam radiation therapy (MBRT) that was used to treat recurrent mucosal melanoma. The patient’s disease recurred after surgery, conventional radiation therapy, and 4 lines of systemic therapy, and then, the patient was referred to our c...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542454825000517 |
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| author | Maddi A. Jacobson, MPAS, PA-C Yasamin Sharifzadeh, MD Arkadiusz Z. Dudek, MD, PhD Svetomir N. Markovic, MD, PhD Jeffrey E. Johnson, MD Jonathan M. Morris, MD Scott C. Lester, MD Robert W. Mutter, MD Michael P. Grams, PhD Sean S. Park, MD, PhD |
| author_facet | Maddi A. Jacobson, MPAS, PA-C Yasamin Sharifzadeh, MD Arkadiusz Z. Dudek, MD, PhD Svetomir N. Markovic, MD, PhD Jeffrey E. Johnson, MD Jonathan M. Morris, MD Scott C. Lester, MD Robert W. Mutter, MD Michael P. Grams, PhD Sean S. Park, MD, PhD |
| author_sort | Maddi A. Jacobson, MPAS, PA-C |
| collection | DOAJ |
| description | We report a case of novel radiation treatment referred to as minibeam radiation therapy (MBRT) that was used to treat recurrent mucosal melanoma. The patient’s disease recurred after surgery, conventional radiation therapy, and 4 lines of systemic therapy, and then, the patient was referred to our clinic. Despite substantial disease progression after multiple prior therapies, a complete metabolic and clinical response, along with an improved quality of life and performance status, was achieved after 2 treatments of MBRT. Additionally, disease response was noted in an unirradiated abdominal metastasis. The MBRT treatments were well-tolerated, with minimal toxicity reported more than 6 months posttreatment. This case highlights the potential of MBRT as a completely novel form of radiation therapy that warrants further study. |
| format | Article |
| id | doaj-art-7ac159c136c941bfb5dc32dcd42b2ebd |
| institution | Kabale University |
| issn | 2542-4548 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| spelling | doaj-art-7ac159c136c941bfb5dc32dcd42b2ebd2025-08-20T03:33:08ZengElsevierMayo Clinic Proceedings: Innovations, Quality & Outcomes2542-45482025-08-019410064010.1016/j.mayocpiqo.2025.100640Minibeam Radiation Therapy for Recurrent Mucosal Melanoma: An Eye-Opening ResponseMaddi A. Jacobson, MPAS, PA-C0Yasamin Sharifzadeh, MD1Arkadiusz Z. Dudek, MD, PhD2Svetomir N. Markovic, MD, PhD3Jeffrey E. Johnson, MD4Jonathan M. Morris, MD5Scott C. Lester, MD6Robert W. Mutter, MD7Michael P. Grams, PhD8Sean S. Park, MD, PhD9Department of Radiation Oncology, Mayo Clinic, Rochester, MNDepartment of Radiation Oncology, Mayo Clinic, Rochester, MNDivision of Medical Oncology, Mayo Clinic, Rochester, MNDivision of Medical Oncology, Mayo Clinic, Rochester, MNDivision of Breast and Melanoma Surgical Oncology, Department of Surgery, Mayo Clinic, Rochester, MNDepartment of Radiology, Mayo Clinic, Rochester, MNDepartment of Radiation Oncology, Mayo Clinic, Rochester, MNDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MNDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN; Correspondence: Address to Michael P. Grams, PhD, Mayo Clinic Department of Radiation Oncology, 200 1st St SW, Rochester, MN 55905.Department of Radiation Oncology, Mayo Clinic, Rochester, MNWe report a case of novel radiation treatment referred to as minibeam radiation therapy (MBRT) that was used to treat recurrent mucosal melanoma. The patient’s disease recurred after surgery, conventional radiation therapy, and 4 lines of systemic therapy, and then, the patient was referred to our clinic. Despite substantial disease progression after multiple prior therapies, a complete metabolic and clinical response, along with an improved quality of life and performance status, was achieved after 2 treatments of MBRT. Additionally, disease response was noted in an unirradiated abdominal metastasis. The MBRT treatments were well-tolerated, with minimal toxicity reported more than 6 months posttreatment. This case highlights the potential of MBRT as a completely novel form of radiation therapy that warrants further study.http://www.sciencedirect.com/science/article/pii/S2542454825000517 |
| spellingShingle | Maddi A. Jacobson, MPAS, PA-C Yasamin Sharifzadeh, MD Arkadiusz Z. Dudek, MD, PhD Svetomir N. Markovic, MD, PhD Jeffrey E. Johnson, MD Jonathan M. Morris, MD Scott C. Lester, MD Robert W. Mutter, MD Michael P. Grams, PhD Sean S. Park, MD, PhD Minibeam Radiation Therapy for Recurrent Mucosal Melanoma: An Eye-Opening Response Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| title | Minibeam Radiation Therapy for Recurrent Mucosal Melanoma: An Eye-Opening Response |
| title_full | Minibeam Radiation Therapy for Recurrent Mucosal Melanoma: An Eye-Opening Response |
| title_fullStr | Minibeam Radiation Therapy for Recurrent Mucosal Melanoma: An Eye-Opening Response |
| title_full_unstemmed | Minibeam Radiation Therapy for Recurrent Mucosal Melanoma: An Eye-Opening Response |
| title_short | Minibeam Radiation Therapy for Recurrent Mucosal Melanoma: An Eye-Opening Response |
| title_sort | minibeam radiation therapy for recurrent mucosal melanoma an eye opening response |
| url | http://www.sciencedirect.com/science/article/pii/S2542454825000517 |
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