Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics
Introduction. Testicular germ cell tumor (GCT) is a rare pathology that accounts for about 1% of all malignant neoplasms in men, while cryptorchidism is one of the main risk factors. We present a clinical case of a GCT of an undescended testicle in patient with bilateral cryptorchidism and male to f...
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| Language: | Russian |
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Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education
2024-11-01
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| Series: | Вестник урологии |
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| Online Access: | https://www.urovest.ru/jour/article/view/961 |
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| author | S. B. Petrov A. V. Arnautov K. A. Nikulina S. A. Reva A. D. Tsaregorodtseva Yu. A. Tikhonova |
| author_facet | S. B. Petrov A. V. Arnautov K. A. Nikulina S. A. Reva A. D. Tsaregorodtseva Yu. A. Tikhonova |
| author_sort | S. B. Petrov |
| collection | DOAJ |
| description | Introduction. Testicular germ cell tumor (GCT) is a rare pathology that accounts for about 1% of all malignant neoplasms in men, while cryptorchidism is one of the main risk factors. We present a clinical case of a GCT of an undescended testicle in patient with bilateral cryptorchidism and male to female sexual characteristics.Objective. To present a rare clinical case of testicular GCT in a patient with disorder of sex development (DSD).Clinical case. A 32-year-old patient with a history of bilateral cryptorchidism with a large neoplasm of the right undescended testis was detected during examination at the Department of Andrology and Oncourology No. 6 of the Pavlov State Medical University. Based on MRI scans, a cavity formation interpreted as an enlarged left seminal vesicle was fixed to the lower pole of the right testicle. Bilateral removal of the left and right testicles (tumour-affected) was performed. The seminal duct was detected from the lower pole of the formation, passing into a blindly ending soft tissue cavity formation (in shape and structure resembling a uterus) — its removal was performed. Histological examination showed that the neoplasm was a typical seminoma of the right testicle, pT2. The soft tissue cavity was represented by a rudimentary uterus with fallopian tubes. Adjuvant chemotherapy was performed.Conclusion. We demonstrate a rare clinical case of a GCT of the undescended testis in a patient with bilateral cryptorchidism, DSD (46, XY), and Müllerian duct persistence syndrome. These nosologies require early diagnosis and treatment. |
| format | Article |
| id | doaj-art-7ac0467edd004c2bbd0f8cfa381c9209 |
| institution | Kabale University |
| issn | 2308-6424 |
| language | Russian |
| publishDate | 2024-11-01 |
| publisher | Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education |
| record_format | Article |
| series | Вестник урологии |
| spelling | doaj-art-7ac0467edd004c2bbd0f8cfa381c92092025-08-20T03:57:22ZrusMinistry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional EducationВестник урологии2308-64242024-11-01125859110.21886/2308-6424-2024-12-5-85-91567Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristicsS. B. Petrov0A. V. Arnautov1K. A. Nikulina2S. A. Reva3A. D. Tsaregorodtseva4Yu. A. Tikhonova5Pavlov First St. Petersburg State Medical UniversityPavlov First St. Petersburg State Medical UniversityPavlov First St. Petersburg State Medical UniversityPavlov First St. Petersburg State Medical UniversityPavlov First St. Petersburg State Medical UniversityPavlov First St. Petersburg State Medical UniversityIntroduction. Testicular germ cell tumor (GCT) is a rare pathology that accounts for about 1% of all malignant neoplasms in men, while cryptorchidism is one of the main risk factors. We present a clinical case of a GCT of an undescended testicle in patient with bilateral cryptorchidism and male to female sexual characteristics.Objective. To present a rare clinical case of testicular GCT in a patient with disorder of sex development (DSD).Clinical case. A 32-year-old patient with a history of bilateral cryptorchidism with a large neoplasm of the right undescended testis was detected during examination at the Department of Andrology and Oncourology No. 6 of the Pavlov State Medical University. Based on MRI scans, a cavity formation interpreted as an enlarged left seminal vesicle was fixed to the lower pole of the right testicle. Bilateral removal of the left and right testicles (tumour-affected) was performed. The seminal duct was detected from the lower pole of the formation, passing into a blindly ending soft tissue cavity formation (in shape and structure resembling a uterus) — its removal was performed. Histological examination showed that the neoplasm was a typical seminoma of the right testicle, pT2. The soft tissue cavity was represented by a rudimentary uterus with fallopian tubes. Adjuvant chemotherapy was performed.Conclusion. We demonstrate a rare clinical case of a GCT of the undescended testis in a patient with bilateral cryptorchidism, DSD (46, XY), and Müllerian duct persistence syndrome. These nosologies require early diagnosis and treatment.https://www.urovest.ru/jour/article/view/961cryptorchidismgerm cell tumorseminomadisorders of sex developmentpseudohermaphroditismtesticular cancerpersistent müllerian duct syndrome |
| spellingShingle | S. B. Petrov A. V. Arnautov K. A. Nikulina S. A. Reva A. D. Tsaregorodtseva Yu. A. Tikhonova Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics Вестник урологии cryptorchidism germ cell tumor seminoma disorders of sex development pseudohermaphroditism testicular cancer persistent müllerian duct syndrome |
| title | Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics |
| title_full | Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics |
| title_fullStr | Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics |
| title_full_unstemmed | Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics |
| title_short | Germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics |
| title_sort | germ cell tumour of an undescended testis diagnosed in a patient with bilateral cryptorchidism presenting both male and female primary sex characteristics |
| topic | cryptorchidism germ cell tumor seminoma disorders of sex development pseudohermaphroditism testicular cancer persistent müllerian duct syndrome |
| url | https://www.urovest.ru/jour/article/view/961 |
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