Repetitive Mild but Not Single Moderate Brain Trauma Is Associated with TAR DNA-Binding Protein 43 Mislocalization and Glial Activation in the Mouse Spinal Cord

Repetitive Mild but Not Single Moderate Brain Trauma Is Associated with TAR DNA-Binding Protein 43 Mislocalization and Glial Activation in the Mouse Spinal Cord

<b>Background/Objectives</b>: Traumatic brain injury (TBI) occurs after a sudden mechanical force to the skull and represents a significant public health problem. Initial brain trauma triggers secondary pathophysiological processes that induce structural and functional impairment of the...

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Bibliographic Details
Main Authors: Tamara Janković, Jelena Rajič Bumber, Nika Gržeta Krpan, Petra Dolenec, Marc Jaeger, Jasna Kriz, Gordana Župan, Kristina Pilipović
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomedicines
Subjects:
traumatic brain injuries
cord
spinal
TDP-43 proteinopathies
microglial cells
neuroinflammation
Online Access:https://www.mdpi.com/2227-9059/13/1/218
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