MRI-based digital twins to improve treatment response of breast cancer by optimizing neoadjuvant chemotherapy regimens

MRI-based digital twins to improve treatment response of breast cancer by optimizing neoadjuvant chemotherapy regimens

Abstract We developed a practical framework to construct digital twins for predicting and optimizing triple-negative breast cancer (TNBC) response to neoadjuvant chemotherapy (NAC). This study employed 105 TNBC patients from the ARTEMIS trial (NCT02276443, registered on 10/21/2014) who received Adri...

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Bibliographic Details
Main Authors: Chengyue Wu, Ernesto A. B. F. Lima, Casey E. Stowers, Zhan Xu, Clinton Yam, Jong Bum Son, Jingfei Ma, Gaiane M. Rauch, Thomas E. Yankeelov
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Digital Medicine
Online Access:https://doi.org/10.1038/s41746-025-01579-1
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