Health-Related Quality of Life in the Gender, Race, And Clinical Experience Trial
Background. We report health-related QoL (HRQoL) from GRACE (Gender, Race, And Clinical Experience) study by sex and race over 48 weeks. Methods. 429 treatment-experienced adults (HIV-1 RNA≥1000 copies/mL) received darunavir/ritonavir 600/100 mg twice daily plus an appropriate background regimen. Qo...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2011/349165 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554296592302080 |
|---|---|
| author | Judith Feinberg Michael Saag Kathleen Squires Judith Currier Robert Ryan Bruce Coate Joseph Mrus |
| author_facet | Judith Feinberg Michael Saag Kathleen Squires Judith Currier Robert Ryan Bruce Coate Joseph Mrus |
| author_sort | Judith Feinberg |
| collection | DOAJ |
| description | Background. We report health-related QoL (HRQoL) from GRACE (Gender, Race, And Clinical Experience) study by sex and race over 48 weeks. Methods. 429 treatment-experienced adults (HIV-1 RNA≥1000 copies/mL) received darunavir/ritonavir 600/100 mg twice daily plus an appropriate background regimen. QoL was measured by the Functional Assessment of HIV Infection (FAHI) questionnaire. Results. 67% women and 77% men, including 67.4% black, 76.0% Hispanic, and 73.8% white patients, completed the trial. Baseline total FAHI scores were similar between sexes and races. Total FAHI of the entire population improved by Week 4 (𝑃<.05); near-maximum changes obtained by Week 12 were maintained through Week 48. Women and black patients demonstrated larger improvements in total FAHI versus men, and Hispanic and white patients, respectively. Conclusion. HRQoL improved in all sex and racial/ethnic groups. Sex-based and race-based differences in improvements in FAHI subscales may provide insight into subtle differences of HIV-1 and treatment on HRQoL in different populations. |
| format | Article |
| id | doaj-art-7ab2fe6bab284dc5900dcae6b572a307 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-7ab2fe6bab284dc5900dcae6b572a3072025-02-03T05:51:53ZengWileyAIDS Research and Treatment2090-12402090-12592011-01-01201110.1155/2011/349165349165Health-Related Quality of Life in the Gender, Race, And Clinical Experience TrialJudith Feinberg0Michael Saag1Kathleen Squires2Judith Currier3Robert Ryan4Bruce Coate5Joseph Mrus6Department of Internal Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USADivision of Infectious Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USADivision of Infectious Diseases and Environmental Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USADavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90035, USAMedical Affairs Biometrics, Tibotec Inc., Titusville, NJ 08560, USAMedical Affairs Biometrics, Tibotec Inc., Titusville, NJ 08560, USAClinical Affairs, Tibotec Therapeutics, Titusville, NJ 08560, USABackground. We report health-related QoL (HRQoL) from GRACE (Gender, Race, And Clinical Experience) study by sex and race over 48 weeks. Methods. 429 treatment-experienced adults (HIV-1 RNA≥1000 copies/mL) received darunavir/ritonavir 600/100 mg twice daily plus an appropriate background regimen. QoL was measured by the Functional Assessment of HIV Infection (FAHI) questionnaire. Results. 67% women and 77% men, including 67.4% black, 76.0% Hispanic, and 73.8% white patients, completed the trial. Baseline total FAHI scores were similar between sexes and races. Total FAHI of the entire population improved by Week 4 (𝑃<.05); near-maximum changes obtained by Week 12 were maintained through Week 48. Women and black patients demonstrated larger improvements in total FAHI versus men, and Hispanic and white patients, respectively. Conclusion. HRQoL improved in all sex and racial/ethnic groups. Sex-based and race-based differences in improvements in FAHI subscales may provide insight into subtle differences of HIV-1 and treatment on HRQoL in different populations.http://dx.doi.org/10.1155/2011/349165 |
| spellingShingle | Judith Feinberg Michael Saag Kathleen Squires Judith Currier Robert Ryan Bruce Coate Joseph Mrus Health-Related Quality of Life in the Gender, Race, And Clinical Experience Trial AIDS Research and Treatment |
| title | Health-Related Quality of Life in the Gender, Race, And Clinical Experience Trial |
| title_full | Health-Related Quality of Life in the Gender, Race, And Clinical Experience Trial |
| title_fullStr | Health-Related Quality of Life in the Gender, Race, And Clinical Experience Trial |
| title_full_unstemmed | Health-Related Quality of Life in the Gender, Race, And Clinical Experience Trial |
| title_short | Health-Related Quality of Life in the Gender, Race, And Clinical Experience Trial |
| title_sort | health related quality of life in the gender race and clinical experience trial |
| url | http://dx.doi.org/10.1155/2011/349165 |
| work_keys_str_mv | AT judithfeinberg healthrelatedqualityoflifeinthegenderraceandclinicalexperiencetrial AT michaelsaag healthrelatedqualityoflifeinthegenderraceandclinicalexperiencetrial AT kathleensquires healthrelatedqualityoflifeinthegenderraceandclinicalexperiencetrial AT judithcurrier healthrelatedqualityoflifeinthegenderraceandclinicalexperiencetrial AT robertryan healthrelatedqualityoflifeinthegenderraceandclinicalexperiencetrial AT brucecoate healthrelatedqualityoflifeinthegenderraceandclinicalexperiencetrial AT josephmrus healthrelatedqualityoflifeinthegenderraceandclinicalexperiencetrial |