Integrating network pharmacology, molecular docking, and animal studies to investigate the protective effect of astragalus polysaccharide on fluoride-induced renal injury in rats

Integrating network pharmacology, molecular docking, and animal studies to investigate the protective effect of astragalus polysaccharide on fluoride-induced renal injury in rats

Fluoride is an essential trace element required for normal physiological functions and holds significant importance for human health. However, excessive fluoride intake can lead to renal damage, for which effective prevention and therapeutic strategies remain scarce. Astragalus polysaccharide (APS),...

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Bibliographic Details
Main Authors: Xiaoyue Zhang, Qianda Yan, Yuanyuan Xiao, Xingyan Du, Xuehua Zhang, Didong Lou, Fang Peng, Daiyong Chen, Wenchao Tang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Fluorides
Renal injury
Astragalus polysaccharide
Network pharmacology
Molecular Docking
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325004452
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