Comparison of pathogen detection performance between metagenomic next-generation sequencing and conventional culture in organ preservation fluids and recipient wound drainage fluids

Comparison of pathogen detection performance between metagenomic next-generation sequencing and conventional culture in organ preservation fluids and recipient wound drainage fluids

BackgroundPrompt identification and management of donor-derived infections post-kidney transplantation are critical. This study aims to assess the effectiveness of metagenomic next-generation sequencing (mNGS) in detecting pathogens within donor organ preservation fluids and recipient wound drainage...

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Main Authors: Jiyuan Li, Wenjia Yuan, Chen Gao, Lei Liu, Lei Song, Wei Cao, Xuejing Zhu, Yachun Han, Ruobing Liang, Gongbin Lan, Shaojie Yu, Yu Wang, Liang Tan, Helong Dai, Xubiao Xie, Longkai Peng, Fenghua Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
kidney transplantation
metagenomic next-generation sequencing
preservation fluid
drainage fluid
donor-derived infection
microbial culture
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1563962/full
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